WO2026062486 - HLA TRIPLE KNOCKOUT HUMAN FOLLICLE CELLS FOR ENHANCED HAIR IMPLANTATION THERAPY WITH INTEGRATED BIOSENSOR SYSTEM
National phase entry is expected:
Publication Number
WO/2026/062486
Publication Date
26.03.2026
International Application No.
PCT/IB2025/059222
International Filing Date
14.09.2025
Title **
[English]
HLA TRIPLE KNOCKOUT HUMAN FOLLICLE CELLS FOR ENHANCED HAIR IMPLANTATION THERAPY WITH INTEGRATED BIOSENSOR SYSTEM
[French]
CELLULES FOLLICULAIRES HUMAINES À TRIPLE INVALIDATION DE HLA POUR UNE THÉRAPIE D'IMPLANTATION CAPILLAIRE AMÉLIORÉE AVEC SYSTÈME DE BIOCAPTEUR INTÉGRÉ
Applicants **
MAHRAT, Reem
Inventors
MAHRAT, Reem
Priority Data
18/887,146
17.09.2024
US
Application details
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International Searching Authority |
ILPO
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| Recordal of a Change of the Applicant's Name/Address |
Change of Applicant's Name and Address
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| Type of Assignment |
The Standard Agent's Assignment
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| Applicant's Legal Status |
Natural Person
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| Entry into National Phase under |
Chapter I
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| Patent Delivery |
Send the Letters Patent by Courier
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| Translation |
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* The data is based on automatic recognition. Please verify and amend if necessary.
** IP-Coster compiles data from publicly available sources. If this data includes your personal information, you can contact us to request its removal.
Quotation for National Phase entry
| Country | Stages | Total | |
|---|---|---|---|
| China | Filing, Examination, Granting | 1987 | |
| EPO | Filing, Examination, Granting | 8677 | |
| Japan | Filing, Examination, Granting | 2030 | |
| South Korea | Filing, Examination, Granting | 1867 | |
| USA | Filing, Examination, Granting | 4740 |
Total:
19,301
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Abstract[English]
The present invention discloses a novel method for developing Human HLA-a/b/c triple knockout hair follicle stem cells (HFSCs) intended for promoting HFSCS transplantation. The method involves precise genetic modification techniques to knockout HLA-a/b/c genes, facilitating enhanced compatibility and effectiveness in hair follicles transplantation. The inventive approach aims to address challenges (donor dependent and large scar) in hair implantation therapy by leveraging advanced gene-editing and stem cell technologies.[French]
La présente invention concerne une nouvelle méthode de développement de cellules souches du follicule pileux (HFSC) à triple invalidation de HLA-a/b/c destinée à favoriser la transplantation de HFSC. La méthode implique des techniques de modification génétique précises pour invalider les gènes HLA-a/b/c, ce qui facilite une compatibilité et une efficacité améliorées dans la transplantation de follicules pileux. L'approche de l'invention vise à répondre aux défis (dépendance vis-à-vis du donneur et cicatrice importante) d'une thérapie d'implantation capillaire par l'exploitation de technologies avancées d'édition de gènes et de cellules souches.