WO2024246713 - A PROCESS FOR THE PREPARATION OF CDK INHIBITING PYRROLOPYRIMIDINE COMPOUNDS
National phase entry is expected:
Publication Number
WO/2024/246713
Publication Date
05.12.2024
International Application No.
PCT/IB2024/055105
International Filing Date
24.05.2024
Title **
[English]
A PROCESS FOR THE PREPARATION OF CDK INHIBITING PYRROLOPYRIMIDINE COMPOUNDS
[French]
PROCÉDÉ DE PRÉPARATION DE COMPOSÉS DE PYRROLOPYRIMIDINE INHIBANT LA CDK
Applicants **
FRESENIUS KABI ONCOLOGY LTD
B-310, Som Dutt Chambers-1, Bhikaji Cama Place
New Delhi 110066, IN
Inventors
NAIN, Sachin
Fresenius Kabi Oncology Limited
Echelon Institutional Area, Plot No - 11
Gurgaon, Haryana 122001, IN
PANDEY, Maneesh Kumar
Fresenius Kabi Oncology Limited
Echelon Institutional Area, Plot No - 11
Gurgaon, Haryana 122001, IN
GIRI, Abhishek
Fresenius Kabi Oncology Limited
Echelon Institutional Area, Plot No - 11
Gurgaon, Haryana 122001, IN
SOKHI, Sarbjot Singh
Fresenius Kabi Oncology Limited
Echelon Institutional Area, Plot No - 11
Gurgaon, Haryana 122001, IN
SINGH, Govind
Fresenius Kabi Oncology Limited
Echelon Institutional Area, Plot No – 11
Gurgaon, Haryana 122001, IN
CABRI, Walter
Fresenius Kabi IPSUM S.R.L.
Via Roma 108
20051 Cassina de’ Pecchi, Milano, IT
Priority Data
202311036980
29.05.2023
IN
Application details
| Total Number of Claims/PCT | * |
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International Searching Authority |
USPTO
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| Applicant's Legal Status |
Legal Entity
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| Entry into National Phase under |
Chapter I
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| Translation |
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Quotation for National Phase entry
| Country | Stages | Total | |
|---|---|---|---|
| China | Filing | 1345 | |
| EPO | Filing, Examination | 9082 | |
| Japan | Filing | 595 | |
| South Korea | Filing | 574 | |
| USA | Filing, Examination | 4080 |
Total: 15676 USD
The term for entry into the National Phase has expired. This quotation is for informational purposes only
Abstract[English]
The present invention relates to an improved process for the preparation of CDK inhibiting pyrrolopyrimidine compounds. More particularly the invention provides a process for preparation of high purity 2'-{[5-(4-methylpiperazin-1-yl)pyridin-2-yl]amino}-7',8' dihydro- 6'H-spiro[cyclohexane-1,9'-pyrazino[1',2':1,5]pyrrolo[2,3-d]pyrimidin]-6'-one which does not involve the use of expensive chemicals, hazardous reagents or tedious purification techniques. Invention also provides novel intermediate useful for preparation of desired compound in high purity.[French]
La présente invention concerne un procédé amélioré pour la préparation de composés pyrrolopyrimidine inhibiteurs de CDK. Plus particulièrement, l'invention concerne un procédé de préparation de 2'-{[5-(4-méthylpipérazin-1-yl) pyridin-2-yl]amino}-7',8'dihydro-6'H-spiro[cyclohexane-1,9'-pyrazino[1',2':1,5]pyrrolo[2,3-d]pyrimidin]-6'-one de haute pureté qui n'implique pas l'utilisation de produits chimiques coûteux, de réactifs dangereux ou de techniques de purification fastidieuses. L'invention concerne également un nouvel intermédiaire utile pour la préparation d'un composé souhaité avec une pureté élevée.