WO2024246713 - A PROCESS FOR THE PREPARATION OF CDK INHIBITING PYRROLOPYRIMIDINE COMPOUNDS
National phase entry is expected:
Publication Number
WO/2024/246713
Publication Date
05.12.2024
International Application No.
PCT/IB2024/055105
International Filing Date
24.05.2024
Title **
[English]
A PROCESS FOR THE PREPARATION OF CDK INHIBITING PYRROLOPYRIMIDINE COMPOUNDS
[French]
PROCÉDÉ DE PRÉPARATION DE COMPOSÉS DE PYRROLOPYRIMIDINE INHIBANT LA CDK
Applicants **
FRESENIUS KABI ONCOLOGY LTD
Inventors
NAIN, Sachin
PANDEY, Maneesh Kumar
GIRI, Abhishek
SOKHI, Sarbjot Singh
SINGH, Govind
CABRI, Walter
Priority Data
202311036980
29.05.2023
IN
Application details
| Total Number of Claims/PCT | * |
| Number of Independent Claims | * |
| Number of Priorities | * |
| Number of Multi-Dependent Claims | * |
| Number of Drawings | * |
| Pages for Publication | * |
| Number of Pages with Drawings | * |
| Pages of Specification | * |
| * | |
| Number of Office Actions | * |
| * | |
International Searching Authority |
USPTO
* |
| * | |
| Recordal of a Change of the Applicant's Name/Address |
Change of Applicant's Name and Address
* |
| Type of Assignment |
The Standard Agent's Assignment
* |
| Applicant's Legal Status |
Legal Entity
* |
| * | |
| * | |
| * | |
| * | |
| * | |
| Entry into National Phase under |
Chapter I
* |
| Patent Delivery |
Send the Letters Patent by Courier
* |
| 译文 |
|
* The data is based on automatic recognition. Please verify and amend if necessary.
** IP-Coster compiles data from publicly available sources. If this data includes your personal information, you can contact us to request its removal.
Quotation for National Phase entry
| Country | Stages | Total | |
|---|---|---|---|
| China | Filing, Examination, Granting | 2349 | |
| EPO | Filing, Examination, Granting | 15659 | |
| Japan | Filing, Examination, Granting | 2400 | |
| South Korea | Filing, Examination, Granting | 2662 | |
| USA | Filing, Examination, Granting | 6110 |
Total:
29,180
The term for entry into the National Phase has expired. This quotation is for informational purposes only
Contact Us
Abstract[English]
The present invention relates to an improved process for the preparation of CDK inhibiting pyrrolopyrimidine compounds. More particularly the invention provides a process for preparation of high purity 2'-{[5-(4-methylpiperazin-1-yl)pyridin-2-yl]amino}-7',8' dihydro- 6'H-spiro[cyclohexane-1,9'-pyrazino[1',2':1,5]pyrrolo[2,3-d]pyrimidin]-6'-one which does not involve the use of expensive chemicals, hazardous reagents or tedious purification techniques. Invention also provides novel intermediate useful for preparation of desired compound in high purity.[French]
La présente invention concerne un procédé amélioré pour la préparation de composés pyrrolopyrimidine inhibiteurs de CDK. Plus particulièrement, l'invention concerne un procédé de préparation de 2'-{[5-(4-méthylpipérazin-1-yl) pyridin-2-yl]amino}-7',8'dihydro-6'H-spiro[cyclohexane-1,9'-pyrazino[1',2':1,5]pyrrolo[2,3-d]pyrimidin]-6'-one de haute pureté qui n'implique pas l'utilisation de produits chimiques coûteux, de réactifs dangereux ou de techniques de purification fastidieuses. L'invention concerne également un nouvel intermédiaire utile pour la préparation d'un composé souhaité avec une pureté élevée.