WO2024116126 - OIL COMPOSITIONS WITH ENGINEERED LIPID PROFILES AND METHODS OF PRODUCING SAME
National phase entry is expected:
Publication Number
WO/2024/116126
Publication Date
06.06.2024
International Application No.
PCT/IB2023/062097
International Filing Date
30.11.2023
Title **
[English]
OIL COMPOSITIONS WITH ENGINEERED LIPID PROFILES AND METHODS OF PRODUCING SAME
[French]
COMPOSITIONS D'HUILE À PROFILS LIPIDIQUES MODIFIÉS ET LEURS PROCÉDÉS DE FABRICATION
Applicants **
MARA RENEWABLES CORPORATION
101A Research Drive
Dartmouth, Nova Scotia B2Y 4T6, CA
Inventors
RASMUSSEN, Holly
c/o Mara Renewables Corporation
101A Research Drive
Dartmouth, Nova Scotia B2Y 4T6, CA
WOODHALL, David
c/o Mara Renewables Corporation
101A Research Drive
Dartmouth, Nova Scotia B2Y 4T6, CA
BENJAMIN, Jeremy
c/o Mara Renewables Corporation
101A Research Drive
Dartmouth, Nova Scotia B2Y 4T6, CA
MUISE, Denise
c/o Mara Renewables Corporation
101A Research Drive
Dartmouth, Nova Scotia B2Y 4T6, CA
ARMENTA, Roberto E.
c/o Mara Renewables Corporation
101A Research Drive
Dartmouth, Nova Scotia B2Y 4T6, CA
Priority Data
63/429,852
02.12.2022
US
Application details
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International Searching Authority |
CIPO
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| Applicant's Legal Status |
Legal Entity
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| Entry into National Phase under |
Chapter I
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| Translation |
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Quotation for National Phase entry
| Country | Stages | Total | |
|---|---|---|---|
| China | Filing | 3126 | |
| EPO | Filing, Examination | 33585 | |
| Japan | Filing | 589 | |
| South Korea | Filing | 575 | |
| USA | Filing, Examination | 13685 |
Total: 51560 USD
The term for entry into the National Phase has expired. This quotation is for informational purposes only
Abstract[English]
Provided herein are engineered microorganisms comprising one or more genes involved in fatty acid metabolism. For example, provided is an engineered microorganism comprising a first nucleic acid sequence encoding an elongase and a second nucleic acid sequence encoding a desaturase, wherein the first and second nucleic acid sequences are operably linked to promoter. Also provided are methods of making and using the engineered microorganisms. Also provided are microbial oils comprising fatty acids, wherein the fatty acids comprise C20:3(n-6) (di-homo-γ-linoleic acid) and C20:5(n-3) eicosapentaenoic acid (EPA). In addition, provided herein are methods of promoting conversion of saturated fatty acids to unsaturated fatty acids by transforming microorganisms with nucleic acid encoding polypeptides involved in the fatty acid synthesis pathway to generated increased conversion of saturated fatty acids to unsaturated fatty acids.[French]
L'invention concerne des micro-organismes modifiés comprenant un ou plusieurs gènes impliqués dans le métabolisme des acides gras. Par exemple, l'invention concerne un micro-organisme modifié comprenant une première séquence d'acide nucléique codant pour une élongase et une deuxième séquence d'acide nucléique codant pour une désaturase, les première et deuxième séquences d'acide nucléique étant fonctionnellement liées à un promoteur. L'invention concerne également des procédés de fabrication et d'utilisation des micro-organismes modifiés. La présente invention concerne également des huiles microbiennes comprenant des acides gras, dans lesquelles les acides gras comprennent l'acide C20:3(n-6) (acide di-homo-γ-linoléique) et l'acide C20:5(n-3) eicosapentaénoïque (EPA). En outre, La présente invention concerne des procédés pour favoriser la conversion des acides gras saturés en acides gras insaturés en transformant des micro-organismes avec des acides nucléiques codant pour des polypeptides impliqués dans la voie de synthèse des acides gras afin de générer une conversion accrue des acides gras saturés en acides gras insaturés.