WO2023194913 - IMMUNOGENIC COMPOSITION USEFUL FOR VACCINATION AGAINST ROTAVIRUS

National phase entry:
Publication Number WO/2023/194913
Publication Date 12.10.2023
International Application No. PCT/IB2023/053433
International Filing Date 04.04.2023
Title **
[English] IMMUNOGENIC COMPOSITION USEFUL FOR VACCINATION AGAINST ROTAVIRUS
[French] COMPOSITION IMMUNOGÈNE UTILE POUR LA VACCINATION CONTRE LES ROTAVIRUS
Applicants **
BOEHRINGER INGELHEIM VETMEDICA GMBH
Inventors
PATTERSON, Abby, Rae
ANSTROM, David, Michael
HAIWICK, Gregory, Brian
JOHNSON, Wesley, Scott
JORDAN, Dianna M. Murphy
NICHOLSON, Bryon
VAUGHN, Eric, Martin
WIDENER, Justin
Priority Data
63/362,488   05.04.2022   US
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Quotation for National Phase entry

Country StagesTotal
China Filing, Examination, Granting3210
EPO Filing, Examination, Granting16788
Japan Filing, Examination, Granting2533
South Korea Filing, Examination, Granting2824
USA Filing, Examination, Granting8240
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Total: 33,595

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Abstract[English] The present invention relates to immunogenic compositions comprising recombinantly constructed polypeptides useful for preparing vaccines, in particular for reducing one or more clinical signs caused by a rotavirus infection. More particular, the present invention is directed to an immunogenic composition containing (i) a fusion protein comprising in N- to C-terminal direction (A) an immunogenic fragment of a rotavirus VP8 protein and (B) an immunoglobulin Fc fragment such as, for example, an IgG Fc fragment, and (ii) an immunogenic substance, different from said fusion protein, wherein said immunogenic composition is usable in a method of reducing one or more clinical signs, mortality or fecal shedding caused by a rotavirus infection in swine.[French] La présente invention concerne des compositions immunogènes comprenant des polypeptides construits par recombinaison utiles pour préparer des vaccins, en particulier pour réduire un ou plusieurs signes cliniques provoqués par une infection à rotavirus. Plus particulièrement, la présente invention concerne une composition immunogène contenant (i) une protéine de fusion comprenant dans la direction N- à C-terminale (A) un fragment immunogène d'une protéine VP8 de rotavirus et (B) un fragment Fc d'immunoglobuline tel que, par exemple, un fragment Fc d'IgG, et (ii) une substance immunogène, différente de ladite protéine de fusion, ladite composition immunogène étant utilisable dans une méthode pour réduire un ou plusieurs signes cliniques, la mortalité ou l'excrétion fécale provoquée par une infection à rotavirus chez le porc.