WO2022259204 - O-LINKED THIADIAZOLYL COMPOUNDS AS DNA POLYMERASE THETA INHIBITORS
National phase entry:
Publication Number
WO/2022/259204
Publication Date
15.12.2022
International Application No.
PCT/IB2022/055384
International Filing Date
09.06.2022
Title **
[English]
O-LINKED THIADIAZOLYL COMPOUNDS AS DNA POLYMERASE THETA INHIBITORS
[French]
COMPOSÉS THIADIAZOLYLE LIÉS À O UTILISÉS EN TANT QU'INHIBITEURS DE L'ADN POLYMÉRASE THÊTA
Applicants **
IDEAYA BIOSCIENCES, INC.
7000 Shoreline Court, Suite 350
South San Francisco, California 94080, US
GLAXOSMITHKLINE INTELLECTUAL PROPERTY (NO.4) LIMITED
GSK Medicines Research Centre
Gunnels Wood Road
Stevenage SG 1 2NY, GB
Inventors
BARSANTI, Paul A.
7000 Shoreline Court, Suite 350
South San Francisco, California 94080, US
JAIPURI, Firoz Ali
7000 Shoreline Court, Suite 350
South San Francisco, California 94080, US
SEVERANCE, Daniel Lee
8439 Torrell Way
San Francisco, California 92126, US
WANG, Chenbo
7000 Shoreline Court, Suite 350
South San Francisco, California 94080, US
DUFFY, Kevin J.
1250 South Collegeville Road
Collegeville, Pennsylvania 19426, US
LAWHORN, Brian G.
123 Ridgewood Circle
Downingtown, Pennsylvania 19335, US
ADAMS, Nicholas David
1250 South Collegeville Road
Collegeville, Pennsylvania 19426, US
BOTYANSZKI, Janos
1250 South Collegeville Road
Collegeville, Pennsylvania 19426, US
DARCY, Michael G.
1250 South Collegeville Road
Collegeville, Pennsylvania 19426, US
KIESOW, Terence J.
1250 South Collegeville Road
Collegeville, Pennsylvania 19426, US
MCATEE, John J.
1250 South Collegeville Road
Collegeville, Pennsylvania 19426, US
MARTYR, Cuthbert
1250 South Collegeville Road
Collegeville, Pennsylvania 19426, US
BUITRAGO SANTANILLA, Alexander
1250 South Collegeville Road
Collegeville, Pennsylvania 19426, US
TIAN, Xinrong
1250 South Collegeville Road
Collegeville, Pennsylvania 19426, US
Priority Data
63/209,555
11.06.2021
US
63/319,826
15.03.2022
US
Application details
| Total Number of Claims/PCT | * |
| Number of Independent Claims | * |
| Number of Priorities | * |
| Number of Multi-Dependent Claims | * |
| Number of Drawings | * |
| Pages for Publication | * |
| Number of Pages with Drawings | * |
| Pages of Specification | * |
| * | |
| * | |
International Searching Authority |
EPO
* |
| Applicant's Legal Status |
Legal Entity
* |
| * | |
| * | |
| * | |
| * | |
| Entry into National Phase under |
Chapter I
* |
| Translation |
|
Recalculate
* The data is based on automatic recognition. Please verify and amend if necessary.
** IP-Coster compiles data from publicly available sources. If this data includes your personal information, you can contact us to request its removal.
Quotation for National Phase entry
| Country | Stages | Total | |
|---|---|---|---|
| China | Filing | 7711 | |
| EPO | Filing, Examination | 42917 | |
| Japan | Filing | 594 | |
| South Korea | Filing | 608 | |
| USA | Filing, Examination | 21910 |
Total: 73740 USD
The term for entry into the National Phase has expired. This quotation is for informational purposes only
Abstract[English]
Disclosed herein are certain thiadiazolyl derivatives Formula (I): (I) that inhibit DNA Polymerase Theta (Pol) activity, in particular inhibit Pol activity by inhibiting ATP dependent helicase domain activity of Pol. Also, disclosed are pharmaceutical compositions comprising such compounds and methods of treating and/or preventing diseases treatable by inhibition of Pol such as cancer, including homologous recombination (HR) deficient cancers.[French]
L'invention concerne certains dérivés de thiadiazolyle de formule (I) : (I) Qui inhibent l'activité de l'ADN polymérase thêta (Pol), en particulier qui inhibent l'activité de Pol par inhibition de l'activité du domaine hélicase dépendant de l'ATP de Pol. L'invention concerne également des compositions pharmaceutiques comprenant de tels composés et des méthodes de traitement et/ou de prévention de maladies pouvant être traitées par inhibition de Pol telles que le cancer, y compris des cancers déficients en recombinaison homologue (HR).