WO2022259204 - O-LINKED THIADIAZOLYL COMPOUNDS AS DNA POLYMERASE THETA INHIBITORS
National phase entry:
Publication Number
WO/2022/259204
Publication Date
15.12.2022
International Application No.
PCT/IB2022/055384
International Filing Date
09.06.2022
Title **
[English]
O-LINKED THIADIAZOLYL COMPOUNDS AS DNA POLYMERASE THETA INHIBITORS
[French]
COMPOSÉS THIADIAZOLYLE LIÉS À O UTILISÉS EN TANT QU'INHIBITEURS DE L'ADN POLYMÉRASE THÊTA
Applicants **
IDEAYA BIOSCIENCES, INC.
GLAXOSMITHKLINE INTELLECTUAL PROPERTY (NO.4) LIMITED
Inventors
BARSANTI, Paul A.
JAIPURI, Firoz Ali
SEVERANCE, Daniel Lee
WANG, Chenbo
DUFFY, Kevin J.
LAWHORN, Brian G.
ADAMS, Nicholas David
BOTYANSZKI, Janos
DARCY, Michael G.
KIESOW, Terence J.
MCATEE, John J.
MARTYR, Cuthbert
BUITRAGO SANTANILLA, Alexander
TIAN, Xinrong
Priority Data
63/209,555
11.06.2021
US
63/319,826
15.03.2022
US
Application details
| Total Number of Claims/PCT | * |
| Number of Independent Claims | * |
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| Number of Multi-Dependent Claims | * |
| Number of Drawings | * |
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International Searching Authority |
EPO
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| Recordal of a Change of the Applicant's Name/Address |
Change of Applicant's Name and Address
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| Type of Assignment |
The Standard Agent's Assignment
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| Applicant's Legal Status |
Legal Entity
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| Entry into National Phase under |
Chapter I
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| Patent Delivery |
Send the Letters Patent by Courier
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| 译文 |
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* The data is based on automatic recognition. Please verify and amend if necessary.
** IP-Coster compiles data from publicly available sources. If this data includes your personal information, you can contact us to request its removal.
Quotation for National Phase entry
| Country | Stages | Total | |
|---|---|---|---|
| China | Filing, Examination, Granting | 8767 | |
| EPO | Filing, Examination, Granting | 66566 | |
| Japan | Filing, Examination, Granting | 3880 | |
| South Korea | Filing, Examination, Granting | 5623 | |
| USA | Filing, Examination, Granting | 23940 |
Total:
108,776
The term for entry into the National Phase has expired. This quotation is for informational purposes only
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Abstract[English]
Disclosed herein are certain thiadiazolyl derivatives Formula (I): (I) that inhibit DNA Polymerase Theta (Pol) activity, in particular inhibit Pol activity by inhibiting ATP dependent helicase domain activity of Pol. Also, disclosed are pharmaceutical compositions comprising such compounds and methods of treating and/or preventing diseases treatable by inhibition of Pol such as cancer, including homologous recombination (HR) deficient cancers.[French]
L'invention concerne certains dérivés de thiadiazolyle de formule (I) : (I) Qui inhibent l'activité de l'ADN polymérase thêta (Pol), en particulier qui inhibent l'activité de Pol par inhibition de l'activité du domaine hélicase dépendant de l'ATP de Pol. L'invention concerne également des compositions pharmaceutiques comprenant de tels composés et des méthodes de traitement et/ou de prévention de maladies pouvant être traitées par inhibition de Pol telles que le cancer, y compris des cancers déficients en recombinaison homologue (HR).