WO2025093467 - METHODS FOR PREVENTING UNWANTED CELLS ARISING DURING DIFFERENTIATION OF HUMAN PLURIPOTENT STEM CELLS
National phase entry is expected:
Publication Number
WO/2025/093467
Publication Date
08.05.2025
International Application No.
PCT/EP2024/080386
International Filing Date
28.10.2024
Title **
[English]
METHODS FOR PREVENTING UNWANTED CELLS ARISING DURING DIFFERENTIATION OF HUMAN PLURIPOTENT STEM CELLS
[French]
PROCÉDÉS POUR EMPÊCHER L'APPARITION DE CELLULES INDÉSIRABLES PENDANT LA DIFFÉRENCIATION DE CELLULES SOUCHES PLURIPOTENTES HUMAINES
Applicants **
NOVO NORDISK A/S
Inventors
HONORÉ, Christian, Le Fèvre
KEMPF, Henning
GÜRTLER, Mads
DJORDJEVIC, Djordje
YANG, Zhang
FROGNE, Thomas
Priority Data
23206929.4
31.10.2023
EP
Application details
| Total Number of Claims/PCT | * |
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International Searching Authority |
EPO
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| Recordal of a Change of the Applicant's Name/Address |
Change of Applicant's Name and Address
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| Type of Assignment |
The Standard Agent's Assignment
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| Applicant's Legal Status |
Legal Entity
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| Entry into National Phase under |
Chapter I
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| Patent Delivery |
Send the Letters Patent by Courier
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| Translation |
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Quotation for National Phase entry
| Country | Stages | Total | |
|---|---|---|---|
| China | Filing, Examination, Granting | 2507 | |
| EPO | Filing, Examination, Granting | 10613 | |
| Japan | Filing, Examination, Granting | 2214 | |
| South Korea | Filing, Examination, Granting | 2200 | |
| USA | Filing, Examination, Granting | 4740 |
Total:
22,274
The term for entry into the National Phase has expired. This quotation is for informational purposes only
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Abstract[English]
differentiation of human pluripotent stem cells into definitive endoderm. The mesodermal cell population formation is inhibited by inactivating in the human pluripotent stem cells one or more genes required for the formation of said cell population. The residual human pluripotent stem cells are eliminated or reduced by culturing the human pluripotent stem cells wherein one or more genes required for the formation of the mesodermal cell population has been inactivated in a medium comprising WNT signalling agonist. The present invention also relates to homogenous cell population of definitive endoderm obtained from such methods.[French]
des cellules souches pluripotentes humaines en endoderme définitif. La formation de population de cellules mésodermiques est inhibée par inactivation dans les cellules souches pluripotentes humaines d'un ou de plusieurs gènes requis pour la formation de ladite population cellulaire. Les cellules souches pluripotentes humaines résiduelles sont éliminées ou réduites par culture des cellules souches pluripotentes humaines, un ou plusieurs gènes requis pour la formation de la population de cellules mésodermiques ayant été inactivés dans un milieu comprenant un agoniste de signalisation WNT. La présente invention concerne également une population cellulaire homogène d'endoderme définitif obtenue selon ces procédés.