WO2026122580 - INSERTION OF LIPID POLYMERS AND IONIZABLE LIPIDS IN EXTRACELLULAR VESICLES FOR THE TARGETING AND DELIVERY OF PAYLOADS TO EUKARYOTIC CELLS
National phase entry is expected:
Publication Number
WO/2026/122580
Publication Date
11.06.2026
International Application No.
PCT/US2025/057745
International Filing Date
02.12.2025
Title **
[English]
INSERTION OF LIPID POLYMERS AND IONIZABLE LIPIDS IN EXTRACELLULAR VESICLES FOR THE TARGETING AND DELIVERY OF PAYLOADS TO EUKARYOTIC CELLS
[French]
INSERTION DE POLYMÈRES LIPIDIQUES ET DE LIPIDES IONISABLES DANS DES VÉSICULES EXTRACELLULAIRES POUR LE CIBLAGE ET LA DISTRIBUTION DE CHARGES UTILES À DES CELLULES EUCARYOTES
Applicants **
ALAYA.BIO INC.
Inventors
BAUCHE, Cecile
VAILLANT, Renaud
PACHERIE, Rachel
MOURLANE, Frederic
JAUDOIN, Celine
BERGALET, Julie
COILLARD, Alice
Priority Data
63/727,123
02.12.2024
US
63/777,996
26.03.2025
US
Application details
| Total Number of Claims/PCT | * |
| Number of Independent Claims | * |
| Number of Priorities | * |
| Number of Multi-Dependent Claims | * |
| Number of Drawings | * |
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| Pages of Specification | * |
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| Number of Office Actions | * |
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International Searching Authority |
EPO
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| Recordal of a Change of the Applicant's Name/Address |
Change of Applicant's Name and Address
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| Type of Assignment |
The Standard Agent's Assignment
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| Applicant's Legal Status |
Legal Entity
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| * | |
| * | |
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| * | |
| * | |
| Entry into National Phase under |
Chapter I
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| Patent Delivery |
Send the Letters Patent by Courier
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| Translation |
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* The data is based on automatic recognition. Please verify and amend if necessary.
** IP-Coster compiles data from publicly available sources. If this data includes your personal information, you can contact us to request its removal.
Quotation for National Phase entry
| Country | Stages | Total | |
|---|---|---|---|
| China | Filing, Examination, Granting | 4152 | |
| EPO | Filing, Examination, Granting | 33597 | |
| Japan | Filing, Examination, Granting | 3324 | |
| South Korea | Filing, Examination, Granting | 4492 | |
| USA | Filing, Examination, Granting | 15240 |
Total:
60,805
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Abstract[English]
The invention relates to the production, modification, and use of extracellular vesicles (EVs), particularly for the delivery of payloads of nucleic acids. The EVs can contain retroviral capsids a polysarcosine polymer grafted on a hydrophobic block, and, optionally, an ionizable lipid, and can be used for the targeted delivery of payloads to cells.[French]
L'invention concerne la production, la modification et l'utilisation de vésicules extracellulaires (VE), en particulier pour l'administration de charges utiles d'acides nucléiques. Les VE peuvent contenir des capsides rétrovirales, un polymère polysarcosine greffé sur un bloc hydrophobe, et, éventuellement, un lipide ionisable, et peuvent être utilisées pour la distribution ciblée de charges utiles à des cellules.