WO2026107057 - STABILIZED GLP-1 PEPTIDES AND DUAL AGONIST PEPTIDES AGAINST GLP-1R AND GIPR AND METHODS OF USE THEREOF

National phase entry is expected:
Publication Number WO/2026/107057
Publication Date 21.05.2026
International Application No. PCT/US2025/055134
International Filing Date 12.11.2025
Title **
[English] STABILIZED GLP-1 PEPTIDES AND DUAL AGONIST PEPTIDES AGAINST GLP-1R AND GIPR AND METHODS OF USE THEREOF
[French] PEPTIDES GLP-1 STABILISÉS ET PEPTIDES AGONISTES DOUBLES CONTRE GLP-1 R ET GIPR ET LEURS PROCÉDÉS D'UTILISATION
Applicants **
BIOMEDIT, INC.
Inventors
KUMAR, Arvind
GANGAIAH, Dharanesh, Mahimapura
VASUDEVAN, Krishnakumar
CAMARA, Ali
PLATA, German
SCHACHT, Aaron
Priority Data
63/720,000   13.11.2024   US
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Quotation for National Phase entry

Country StagesTotal
China Filing, Examination, Granting4173
EPO Filing, Examination, Granting31990
Japan Filing, Examination, Granting3110
South Korea Filing, Examination, Granting4185
USA Filing, Examination, Granting20010
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Total: 63,468
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Abstract[English] The present application provides protease-resistant Glucagon-Like Peptide 1 (eGLP-1) peptides, and also provides protease-resistant dual agonist peptides against GLP-1R and GIPR, methods of making such peptides, as well as compositions comprising protease-resistant peptides and methods of treatment utilizing such peptides. The application further provides variant albumin binding domain (ABD) sequences and peptides, compositions thereof, constructs and polypeptides including the variant ABD sequences, and methods utilizing such sequences and polypeptides.[French] La présente invention concerne des peptides de peptide 1 de type glucagon résistant aux protéases (eGLP-1), et fournit également des peptides agonistes doubles résistants aux protéases contre GLP-1R et GIPR, des procédés de fabrication de tels peptides, ainsi que des compositions comprenant des peptides résistants aux protéases et des procédés de traitement utilisant de tels peptides. L'invention concerne en outre des séquences et des peptides de domaine de liaison à l'albumine variants (ABD), des compositions de ceux-ci, des constructions et des polypeptides comprenant les séquences ABD variantes, et des procédés utilisant de telles séquences et polypeptides.