WO2025194057 - MACROCYCLIC COMPOUNDS AS MODULATORS OF KRAS AND USES THEREOF
National phase entry is expected:
Publication Number
WO/2025/194057
Publication Date
18.09.2025
International Application No.
PCT/US2025/019964
International Filing Date
14.03.2025
Title **
[English]
MACROCYCLIC COMPOUNDS AS MODULATORS OF KRAS AND USES THEREOF
[French]
COMPOSÉS MACROCYCLIQUES UTILISÉS EN TANT QUE MODULATEURS DE KRAS ET LEURS UTILISATIONS
Applicants **
AMGEN INC.
Inventors
WURZ, Ryan Paul
CHEN, Ning
LIU, Qingyian
EMMETIERE, Fabien
JACKSON, Jeffrey
AMEGADZIE, Albert K.
YAMANO, Michael Masaharu
BOOKER, Shon
TAO, Yujia
TANWAR, Lalita
TERCENIO, Quentin
PETTUS, Liping H.
ZHAO, Wei
LANMAN, Brian Alan
LI, Yunxiao
Priority Data
63/565,479
14.03.2024
US
63/645,701
10.05.2024
US
Application details
| Total Number of Claims/PCT | * |
| Number of Independent Claims | * |
| Number of Priorities | * |
| Number of Multi-Dependent Claims | * |
| Number of Drawings | * |
| Pages for Publication | * |
| Number of Pages with Drawings | * |
| Pages of Specification | * |
| * | |
| Number of Office Actions | * |
| * | |
International Searching Authority |
EPO
* |
| Recordal of a Change of the Applicant's Name/Address |
Change of Applicant's Name and Address
* |
| Type of Assignment |
The Standard Agent's Assignment
* |
| Applicant's Legal Status |
Legal Entity
* |
| * | |
| * | |
| * | |
| * | |
| * | |
| Entry into National Phase under |
Chapter I
* |
| Patent Delivery |
Send the Letters Patent by Courier
* |
| Translation |
|
* The data is based on automatic recognition. Please verify and amend if necessary.
** IP-Coster compiles data from publicly available sources. If this data includes your personal information, you can contact us to request its removal.
Quotation for National Phase entry
| Country | Stages | Total | |
|---|---|---|---|
| China | Filing, Examination, Granting | 5610 | |
| EPO | Filing, Examination, Granting | 64768 | |
| Japan | Filing, Examination, Granting | 4007 | |
| South Korea | Filing, Examination, Granting | 5877 | |
| USA | Filing, Examination, Granting | 19940 |
Total:
100,202
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Abstract[English]
Disclosed herein are compounds useful for the inhibition of KRAS G12D, G12V, G12A, G12S, G12R, G13D, Q61H, Q61L, Q61R or G12C. The compounds have a general Formula (I): or pharmaceutically acceptable salts thereof, wherein the variables of Formula (I) are as defined herein. Also provided herein are pharmaceutical compositions comprising the compounds, uses of the compounds, and compositions for treatment of, for example, a KRAS G12D, G12V, G12A, G12S, G12R, G13D, Q61H, Q61L, Q61R or G12C disorder.[French]
L'invention concerne des composés utiles pour l'inhibition de KRAS G12D, G12V, G12A, G12S, G12R, G13D, Q61H, Q61L, Q61R ou G12C. Les composés ont une formule générale (I) : ou des sels pharmaceutiquement acceptables de ceux-ci, les variables de formule (I) étant telles que définies dans la description. L'invention concerne également des compositions pharmaceutiques comprenant les composés, des utilisations des composés, et des compositions pour le traitement, par exemple, d'un trouble KRAS G12D, G12V, G12A, G12S, G12R, G13D, Q61H, Q61L, Q61R ou G12C.