WO2025198930 - SMALL MOLECULES AS KCNQ2/3 (KV7.2/3) CHANNEL ACTIVATORS AND THEIR MEDICAL USE THEREOF
National phase entry is expected:
Publication Number
WO/2025/198930
Publication Date
25.09.2025
International Application No.
PCT/US2025/019726
International Filing Date
13.03.2025
Title **
[English]
SMALL MOLECULES AS KCNQ2/3 (KV7.2/3) CHANNEL ACTIVATORS AND THEIR MEDICAL USE THEREOF
[French]
PETITES MOLÉCULES EN TANT QU'ACTIVATEURS DE CANAUX KCNQ2/3 (KV7.2/3) ET LEUR UTILISATION MÉDICALE
Applicants **
YICHANG HUMANWELL PHARMACEUTICAL CO.,LTD.
Inventors
DOU, Xiaozheng
KAUSHIK, Shivansh
ZHAO, Shuo
SUN, Haizhou
LIAO, Subo
YANG, Jun
ZHOU, Hao
LIU, Rong
DING, Zejian
MOU, Xiongjun
Priority Data
63/566,668
18.03.2024
US
63/682,521
13.08.2024
US
Application details
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International Searching Authority |
USPTO
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| Recordal of a Change of the Applicant's Name/Address |
Change of Applicant's Name and Address
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| Type of Assignment |
The Standard Agent's Assignment
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| Applicant's Legal Status |
Legal Entity
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| Entry into National Phase under |
Chapter I
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| Patent Delivery |
Send the Letters Patent by Courier
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| Translation |
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* The data is based on automatic recognition. Please verify and amend if necessary.
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Quotation for National Phase entry
| Country | Stages | Total | |
|---|---|---|---|
| China | Filing, Examination, Granting | 2731 | |
| EPO | Filing, Examination, Granting | 14130 | |
| Japan | Filing, Examination, Granting | 2061 | |
| South Korea | Filing, Examination, Granting | 1970 | |
| USA | Filing, Examination, Granting | 5360 |
Total:
26,252
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Abstract[English]
The present invention relates to a novel class of bicyclic derivatives that function as small-molecule KCQN2/3 (Kv7.2/3) potassium channel activators, along with their pharmaceutical composition, method of preparation, and therapeutic applications. These compounds, represented by Formula (I), and defined by specific substituents and structural characteristics as described in the specification. By modulating or enhancing the activation of Kv7.2/3 potassium channels, these derivatives hold therapeutic potential for treating seizure disorders and other conditions influenced by potassium ion channel modulation.[French]
La présente invention concerne une nouvelle classe de dérivés bicycliques qui fonctionnent en tant qu'activateurs de canaux potassiques KCQN2/3 (Kv7.2/3) à petites molécules, ainsi que leur composition pharmaceutique, leur procédé de préparation et leurs applications thérapeutiques. Ces composés sont représentés par la formule (I) et définis par des substituants spécifiques et des caractéristiques structurales tels que décrits dans la description. En modulant ou en améliorant l'activation de canaux potassiques Kv7.2/3, ces dérivés maintiennent un potentiel thérapeutique pour le traitement de troubles épileptiques et d'autres conditions influencées par la modulation des canaux ioniques potassiques.