WO2024163309 - ENHANCING COUPLED CATALYTIC ACTIVITY OF MULTI-ENZYME CASCADES WITH LIQUID-LIQUID PHASE SEPARATION USING PEPTIDE-BASED CONDENSATES
National phase entry is expected:
Publication Number
WO/2024/163309
Publication Date
08.08.2024
International Application No.
PCT/US2024/013271
International Filing Date
29.01.2024
Title **
[English]
ENHANCING COUPLED CATALYTIC ACTIVITY OF MULTI-ENZYME CASCADES WITH LIQUID-LIQUID PHASE SEPARATION USING PEPTIDE-BASED CONDENSATES
[French]
AMÉLIORATION DE L'ACTIVITÉ CATALYTIQUE COUPLÉE DE CASCADES MULTI-ENZYMES AVEC SÉPARATION DE PHASE LIQUIDE-LIQUIDE À L'AIDE DE CONDENSATS À BASE DE PEPTIDES
Applicants **
THE GOVERNMENT OF THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY OF THE NAVY
Inventors
BREGER, Joyce
SUSUMU, Kimihiro
MEDINTZ, Igor
ELLIS, Gregory
DIAZ, Sebastian
HOOE, Shelby
Priority Data
63/482,369
31.01.2023
US
Application details
| Total Number of Claims/PCT | * |
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| Number of Multi-Dependent Claims | * |
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International Searching Authority |
MOIP
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| Recordal of a Change of the Applicant's Name/Address |
Change of Applicant's Name and Address
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| Type of Assignment |
The Standard Agent's Assignment
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| Applicant's Legal Status |
Legal Entity
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| Entry into National Phase under |
Chapter I
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| Patent Delivery |
Send the Letters Patent by Courier
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| Translation |
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Quotation for National Phase entry
| Country | Stages | Total | |
|---|---|---|---|
| China | Filing, Examination, Granting | 1964 | |
| EPO | Filing, Examination, Granting | 11752 | |
| Japan | Filing, Examination, Granting | 2023 | |
| South Korea | Filing, Examination, Granting | 1442 | |
| USA | Filing, Examination, Granting | 4740 |
Total:
21,921
The term for entry into the National Phase has expired. This quotation is for informational purposes only
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Abstract[English]
Enzyme cascade reactions, wherein the product of a first enzyme is the substrate of a second enzyme and so forth, were found to be enhanced by the presence of peptides. It is believed that the peptides operate by forming coacervates, which are membrane-less compartments where, in the case of coacervates formed by peptides, the liquid-liquid phase separation involves water as the continuous phase both inside and outside the coacervate.[French]
Des réactions en cascade enzymatique, dans lesquelles le produit d'une première enzyme est le substrat d'une deuxième enzyme et ainsi de suite, se sont avérés être améliorés par la présence de peptides. On pense que les peptides fonctionnent en formant des coacervats, qui sont des compartiments sans membrane où, dans le cas de coacervats formés par des peptides, la séparation de phase liquide-liquide implique de l'eau en tant que phase continue à la fois à l'intérieur et à l'extérieur du coacervat.