WO2024163309 - ENHANCING COUPLED CATALYTIC ACTIVITY OF MULTI-ENZYME CASCADES WITH LIQUID-LIQUID PHASE SEPARATION USING PEPTIDE-BASED CONDENSATES
National phase entry is expected:
Publication Number
WO/2024/163309
Publication Date
08.08.2024
International Application No.
PCT/US2024/013271
International Filing Date
29.01.2024
Title **
[English]
ENHANCING COUPLED CATALYTIC ACTIVITY OF MULTI-ENZYME CASCADES WITH LIQUID-LIQUID PHASE SEPARATION USING PEPTIDE-BASED CONDENSATES
[French]
AMÉLIORATION DE L'ACTIVITÉ CATALYTIQUE COUPLÉE DE CASCADES MULTI-ENZYMES AVEC SÉPARATION DE PHASE LIQUIDE-LIQUIDE À L'AIDE DE CONDENSATS À BASE DE PEPTIDES
Applicants **
THE GOVERNMENT OF THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY OF THE NAVY
Naval Research Laboratory
875 North Randolph Street, Suite 1425
Arlington, Virginia 22203, US
Inventors
BREGER, Joyce
4555 Overlook Ave SW
Washington, District of Columbia 20375, US
SUSUMU, Kimihiro
4555 Overlook Ave., SW
Washington, District of Columbia 20375, US
MEDINTZ, Igor
4555 Overlook Ave SW
Washington, District of Columbia 20375, US
ELLIS, Gregory
4555 Overlook Ave SW
Washington, District of Columbia 20375, US
DIAZ, Sebastian
4555 Overlook Ave SW
Washington, District of Columbia 20375, US
HOOE, Shelby
4555 Overlook Ave SW
Washington, District of Columbia 20375, US
Priority Data
63/482,369
31.01.2023
US
Application details
| Total Number of Claims/PCT | * |
| Number of Independent Claims | * |
| Number of Priorities | * |
| Number of Multi-Dependent Claims | * |
| Number of Drawings | * |
| Pages for Publication | * |
| Number of Pages with Drawings | * |
| Pages of Specification | * |
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International Searching Authority |
MOIP
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| Applicant's Legal Status |
Legal Entity
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| * | |
| * | |
| * | |
| * | |
| Entry into National Phase under |
Chapter I
* |
| Translation |
|
Recalculate
* The data is based on automatic recognition. Please verify and amend if necessary.
** IP-Coster compiles data from publicly available sources. If this data includes your personal information, you can contact us to request its removal.
Quotation for National Phase entry
| Country | Stages | Total | |
|---|---|---|---|
| China | Filing | 961 | |
| EPO | Filing, Examination | 6349 | |
| Japan | Filing | 587 | |
| South Korea | Filing | 574 | |
| USA | Filing, Examination | 2710 |
Total: 11181 USD
The term for entry into the National Phase has expired. This quotation is for informational purposes only
Abstract[English]
Enzyme cascade reactions, wherein the product of a first enzyme is the substrate of a second enzyme and so forth, were found to be enhanced by the presence of peptides. It is believed that the peptides operate by forming coacervates, which are membrane-less compartments where, in the case of coacervates formed by peptides, the liquid-liquid phase separation involves water as the continuous phase both inside and outside the coacervate.[French]
Des réactions en cascade enzymatique, dans lesquelles le produit d'une première enzyme est le substrat d'une deuxième enzyme et ainsi de suite, se sont avérés être améliorés par la présence de peptides. On pense que les peptides fonctionnent en formant des coacervats, qui sont des compartiments sans membrane où, dans le cas de coacervats formés par des peptides, la séparation de phase liquide-liquide implique de l'eau en tant que phase continue à la fois à l'intérieur et à l'extérieur du coacervat.