WO2024011098 - QUANTUM DOT-NUCLEOTIDE BASED RATIOMETRIC FLUORESCENT MOLECULAR BEACON FOR QUANTITATIVE CRISPR/CAS ACTIVITY DETECTION
National phase entry is expected:
Publication Number
WO/2024/011098
Publication Date
11.01.2024
International Application No.
PCT/US2023/069601
International Filing Date
05.07.2023
Title **
[English]
QUANTUM DOT-NUCLEOTIDE BASED RATIOMETRIC FLUORESCENT MOLECULAR BEACON FOR QUANTITATIVE CRISPR/CAS ACTIVITY DETECTION
[French]
BALISE MOLÉCULAIRE FLUORESCENTE RATIOMÉTRIQUE FONDÉE SUR DES NUCLÉOTIDES À POINTS QUANTIQUES POUR LA DÉTECTION QUANTITATIVE DE L'ACTIVITÉ CRISPR/CAS
Applicants **
THE GOVERNMENT OF THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY OF THE NAVY
Naval Research Laboratory
875 North Randolph Street, Suite 1425
Arlington, Virginia 22203, US
Inventors
DÍAZ, Sebastián
4555 Overlook Ave SW
Washington, District of Columbia, US
GREEN, Christopher
4555 Overlook Ave SW
Washington, District of Columbia, US
SPANGLER, Joseph
4555 Overlook Ave SW
Washington, District of Columbia, US
MATHUR, Divita
4555 Overlook Ave SW
Washington, District of Columbia, US
SUSUMU, Kimihiro
4555 Overlook Ave., SW
Washington, District of Columbia 20375, US
STENGER, David
4555 Overlook Ave SW
Washington, District of Columbia 20375, US
MEDINTZ, Igor
4555 Overlook Ave SW
Washington, District of Columbia 20375, US
Priority Data
63/358,719
06.07.2022
US
Quotation for National Phase entry
Abstract[English]
A flexible strategy for assembling luminescent and colorimetric quantum dot/nucleic acid hairpin (QD-HP) molecular beacons for use in CRISPR/Cas diagnostics uses chimeric peptide/peptide nucleic acid (PNA) to conjugate fluorescently labeled DNA or RNA hairpins to ZnS-coated QDs.[French]
Stratégie souple d'assemblage de balises moléculaires luminescentes et colorimétriques fondées sur des points quantiques et des épingles à cheveux d'acide nucléique (QD-HP), à utiliser dans les diagnostics CRISPR/Cas, utilisant des peptides chimériques et des acides nucléiques peptidiques (ANP) pour conjuguer des épingles à cheveux d'ADN ou d'ARN marquées de manière fluorescente à des QD revêtus de ZnS.