WO2024011098 - QUANTUM DOT-NUCLEOTIDE BASED RATIOMETRIC FLUORESCENT MOLECULAR BEACON FOR QUANTITATIVE CRISPR/CAS ACTIVITY DETECTION
National phase entry is expected:
Publication Number
WO/2024/011098
Publication Date
11.01.2024
International Application No.
PCT/US2023/069601
International Filing Date
05.07.2023
Title **
[English]
QUANTUM DOT-NUCLEOTIDE BASED RATIOMETRIC FLUORESCENT MOLECULAR BEACON FOR QUANTITATIVE CRISPR/CAS ACTIVITY DETECTION
[French]
BALISE MOLÉCULAIRE FLUORESCENTE RATIOMÉTRIQUE FONDÉE SUR DES NUCLÉOTIDES À POINTS QUANTIQUES POUR LA DÉTECTION QUANTITATIVE DE L'ACTIVITÉ CRISPR/CAS
Applicants **
THE GOVERNMENT OF THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY OF THE NAVY
Inventors
DÍAZ, Sebastián
GREEN, Christopher
SPANGLER, Joseph
MATHUR, Divita
SUSUMU, Kimihiro
STENGER, David
MEDINTZ, Igor
Priority Data
63/358,719
06.07.2022
US
Application details
| Total Number of Claims/PCT | * |
| Number of Independent Claims | * |
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| Number of Multi-Dependent Claims | * |
| Number of Drawings | * |
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International Searching Authority |
MOIP
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| Recordal of a Change of the Applicant's Name/Address |
Change of Applicant's Name and Address
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| Type of Assignment |
The Standard Agent's Assignment
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| Applicant's Legal Status |
Legal Entity
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| * | |
| * | |
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| Entry into National Phase under |
Chapter I
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| Patent Delivery |
Send the Letters Patent by Courier
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| Translation |
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* The data is based on automatic recognition. Please verify and amend if necessary.
** IP-Coster compiles data from publicly available sources. If this data includes your personal information, you can contact us to request its removal.
Quotation for National Phase entry
| Country | Stages | Total | |
|---|---|---|---|
| China | Filing, Examination, Granting | 1978 | |
| EPO | Filing, Examination, Granting | 11483 | |
| Japan | Filing, Examination, Granting | 2059 | |
| South Korea | Filing, Examination, Granting | 1496 | |
| USA | Filing, Examination, Granting | 5340 |
Total:
22,356
The term for entry into the National Phase has expired. This quotation is for informational purposes only
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Abstract[English]
A flexible strategy for assembling luminescent and colorimetric quantum dot/nucleic acid hairpin (QD-HP) molecular beacons for use in CRISPR/Cas diagnostics uses chimeric peptide/peptide nucleic acid (PNA) to conjugate fluorescently labeled DNA or RNA hairpins to ZnS-coated QDs.[French]
Stratégie souple d'assemblage de balises moléculaires luminescentes et colorimétriques fondées sur des points quantiques et des épingles à cheveux d'acide nucléique (QD-HP), à utiliser dans les diagnostics CRISPR/Cas, utilisant des peptides chimériques et des acides nucléiques peptidiques (ANP) pour conjuguer des épingles à cheveux d'ADN ou d'ARN marquées de manière fluorescente à des QD revêtus de ZnS.