WO2024076484 - METHODS FOR DETERMINATION AND MONITORING OF XENOTRANSPLANT REJECTION BY MEASURING NUCLEIC ACIDS OR PROTEINS DERIVED FROM THE XENOTRANSPLANT
National phase entry is expected:
Publication Number
WO/2024/076484
Publication Date
11.04.2024
International Application No.
PCT/US2023/033874
International Filing Date
27.09.2023
Title **
[English]
METHODS FOR DETERMINATION AND MONITORING OF XENOTRANSPLANT REJECTION BY MEASURING NUCLEIC ACIDS OR PROTEINS DERIVED FROM THE XENOTRANSPLANT
[French]
PROCÉDÉS SERVANT À DIAGNOSTIQUER ET À SURVEILLER LE REJET D'UNE XÉNOGREFFE PAR MESURE DES PROTÉINES OU DES ACIDES NUCLÉIQUES DÉRIVÉS DE LA XÉNOGREFFE
Applicants **
NATERA, INC.
201 Industrial Road, Suite 410
San Carlos, California 94070, US
Inventors
CONSTANTIN, Tudor Pompiliu
201 Industrial Road, Suite 410
San Carlos, California 94070, US
ZIMMERMANN, Bernhard
201 Industrial Road, Suite 410
San Carlos, California 94070, US
HEILEK, Gabrielle
201 Industrial Road, Suite 410
San Carlos, California 94070, US
WONG, Swee Seong
201 Industrial Road, Suite 410
San Carlos, California 94070, US
Priority Data
63/413,738
06.10.2022
US
Application details
| Total Number of Claims/PCT | * |
| Number of Independent Claims | * |
| Number of Priorities | * |
| Number of Multi-Dependent Claims | * |
| Number of Drawings | * |
| Pages for Publication | * |
| Number of Pages with Drawings | * |
| Pages of Specification | * |
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| * | |
International Searching Authority |
EPO
* |
| Applicant's Legal Status |
Legal Entity
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| * | |
| * | |
| * | |
| * | |
| Entry into National Phase under |
Chapter I
* |
| Translation |
|
Recalculate
* The data is based on automatic recognition. Please verify and amend if necessary.
** IP-Coster compiles data from publicly available sources. If this data includes your personal information, you can contact us to request its removal.
Quotation for National Phase entry
| Country | Stages | Total | |
|---|---|---|---|
| China | Filing | 2751 | |
| EPO | Filing, Examination | 19906 | |
| Japan | Filing | 602 | |
| South Korea | Filing | 576 | |
| USA | Filing, Examination | 13685 |
Total: 37520 USD
The term for entry into the National Phase has expired. This quotation is for informational purposes only
Abstract[English]
The present disclosure provides methods for preparation and analysis of biological samples of xenotransplant recipients, wherein the methods comprise extracting fragmented or intact cell-free DNA, RNA (such as mRNA or miRNA), or protein derived from sample of the xenotransplant recipient, and measuring amounts of cell-free DNA, RNA (such as mRNA or miRNA), or protein derived from the xenotransplant enables assessment of xenotransplant rejection. The detection of the cell-free DNA, or RNA may be performed by preparing sequencing libraries and performing whole genome sequencing.[French]
La présente invention concerne des procédés servant à préparer et à analyser des échantillons biologiques provenant de receveurs de xénogreffe, les procédés comprenant l'extraction d'ARN (tel que l'ARNm ou le miARN), ou d'ADN acellulaires, fragmentés ou intacts, ou d'une protéine, dérivés d'un échantillon du receveur de xénogreffe, et la mesure des quantités d'ARN (tel que l'ARNm ou le miARN), ou d'ADN acellulaires ou de protéines, dérivés de la xénogreffe, ce qui permet de déterminer le rejet d'une xénogreffe. La détection de l'ARN ou de l'ADN acellulaires peut être effectuée en préparant des banques de séquençage et en réalisant un séquençage de génome entier.