WO2024076469 - NON-INVASIVE METHODS OF ASSESSING TRANSPLANT REJECTION IN PREGNANT TRANSPLANT RECIPIENTS
National phase entry:
Publication Number
WO/2024/076469
Publication Date
11.04.2024
International Application No.
PCT/US2023/033299
International Filing Date
20.09.2023
Title **
[English]
NON-INVASIVE METHODS OF ASSESSING TRANSPLANT REJECTION IN PREGNANT TRANSPLANT RECIPIENTS
[French]
PROCÉDÉS NON INVASIFS D'ÉVALUATION DU REJET DE GREFFE CHEZ LES RECEVEUSES DE GREFFE ENCEINTES
Applicants **
NATERA, INC.
Inventors
TANG, Jessica
WOODRUFF, Kate
VU, Phikhanh
SOTTO, Chris
AHMED, Ebad
VAN HUMMELEN, Paul
HEILEK, Gabrielle
ZIMMERMANN, Bernhard
TABRIZIANI, Hossein
Priority Data
63/413,750
06.10.2022
US
63/440,251
20.01.2023
US
63/530,828
04.08.2023
US
Application details
| Total Number of Claims/PCT | * |
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International Searching Authority |
EPO
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| Recordal of a Change of the Applicant's Name/Address |
Change of Applicant's Name and Address
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| Type of Assignment |
The Standard Agent's Assignment
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| Applicant's Legal Status |
Legal Entity
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| Entry into National Phase under |
Chapter I
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| Patent Delivery |
Send the Letters Patent by Courier
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| Translation |
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Quotation for National Phase entry
| Country | Stages | Total | |
|---|---|---|---|
| China | Filing, Examination, Granting | 2636 | |
| EPO | Filing, Examination, Granting | 12812 | |
| Japan | Filing, Examination, Granting | 2370 | |
| South Korea | Filing, Examination, Granting | 2571 | |
| USA | Filing, Examination, Granting | 5140 |
Total:
25,529
The term for entry into the National Phase has expired. This quotation is for informational purposes only
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Abstract[English]
The present disclosure provides methods for preparation and analysis of biological samples of maternal transplant recipients, wherein the methods comprise extracting cell-free DNA from the recipient, wherein the cell-free DNA comprises donor-derived cell-free DNA, recipient-derived cell-free DNA, and fetal-derived cell-free DNA, and measuring amounts of cell-free DNA and donor-derived cell-free DNA enables assessment of transplant rejection. The detection of the donor-derived cell-free DNA may be performed based on loci at which the maternal transplant recipient and biological father of the fetus are homozygous and the transplant donor is heterozygous.[French]
La présente invention concerne des procédés de préparation et d'analyse d'échantillons biologiques de receveurs de greffes maternelles, les procédés consistant à extraire l'ADN acellulaire de la receveuse, l'ADN acellulaire comprenant l'ADN acellulaire dérivé de la donneuse, l'ADN acellulaire dérivé de la receveuse et l'ADN acellulaire dérivé du fœtus, et la mesure des quantités d'ADN acellulaire et d'ADN acellulaire provenant de la donneuse permettant d'évaluer le rejet de la greffe. La détection de l'ADN acellulaire provenant de la donneuse peut être fondée sur des loci pour lesquels la receveuse de la greffe maternelle et le père biologique du fœtus sont homozygotes et la donneuse de la greffe est hétérozygote.