WO2023244274 - COMPOSITION OF A LIPOPHILIC AGENT FOR SOLUTION PHASE SYNTHESIS OF BIOMOLECULES
National phase entry:
Publication Number
WO/2023/244274
Publication Date
21.12.2023
International Application No.
PCT/US2022/076675
International Filing Date
19.09.2022
Title **
[English]
COMPOSITION OF A LIPOPHILIC AGENT FOR SOLUTION PHASE SYNTHESIS OF BIOMOLECULES
[French]
COMPOSITION D'UN AGENT LIPOPHILE POUR LA SYNTHÈSE EN PHASE SOLUTION DE BIOMOLÉCULES
Applicants **
LI, Yongfu
Inventors
LI, Yongfu
Priority Data
17/748,292
19.05.2022
US
Application details
| Total Number of Claims/PCT | * |
| Number of Independent Claims | * |
| Number of Priorities | * |
| Number of Multi-Dependent Claims | * |
| Number of Drawings | * |
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International Searching Authority |
USPTO
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| Recordal of a Change of the Applicant's Name/Address |
Change of Applicant's Name and Address
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| Type of Assignment |
The Standard Agent's Assignment
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| Applicant's Legal Status |
Natural Person
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| * | |
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| Entry into National Phase under |
Chapter I
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| Patent Delivery |
Send the Letters Patent by Courier
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| Translation |
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* The data is based on automatic recognition. Please verify and amend if necessary.
** IP-Coster compiles data from publicly available sources. If this data includes your personal information, you can contact us to request its removal.
Quotation for National Phase entry
| Country | Stages | Total | |
|---|---|---|---|
| China | Filing, Examination, Granting | 2314 | |
| EPO | Filing, Examination, Granting | 10316 | |
| Japan | Filing, Examination, Granting | 2305 | |
| South Korea | Filing, Examination, Granting | 2335 | |
| USA | Filing, Examination, Granting | 4310 |
Total:
21,580
The term for entry into the National Phase has expired. This quotation is for informational purposes only
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Abstract[English]
Disclosed is a lipophilic agent comprising a triazine core having lipophilic groups for organic synthesis. The lipophilic agent soluble in one system of solvent(s) wherein the lipophilic agent is participated in a chemical reaction but insoluble by adding a miscible poor solvent to change solution composition after the reaction completes. The lipophilic agent facilitates process improvement wherein practical operation only involves mixing with reactants in solution followed by precipitating with change of solution composition followed by filtering to obtain the precipitated solid, simplifying the purification by isolating the desired solid. The operation is reproducible along the progress in a multi-step synthesis, allowing pure intermediates and pure product as a solid to be rapidly obtained with ease and certainty. This invention can thus accelerate research and development of pharmaceutical biomolecules, representing a tremendous step forward for boosting productivity and greening chemical industry.[French]
L'invention concerne un agent lipophile comprenant un noyau de triazine ayant des groupes lipophiles pour la synthèse organique. L'agent lipophile est soluble dans un système de solvant(s), l'agent lipophile participe à une réaction chimique mais est insoluble du fait de l'ajout d'un solvant faiblement miscible pour changer la composition de solution après que la réaction s'achève. L'agent lipophile permet l'amélioration du processus, une opération pratique impliquant uniquement le mélange avec des réactifs en solution, puis la précipitation avec un changement de composition de solution suivie d'un filtrage pour obtenir le solide précipité, ce qui simplifie la purification en isolant le solide souhaité. L'opération est reproductible tout au long de la progression dans une synthèse en plusieurs étapes, ce qui permet d'obtenir rapidement des intermédiaires purs et un produit pur en tant que solide avec facilité et certitude. La présente invention peut ainsi accélérer la recherche et le développement de biomolécules pharmaceutiques, représentant une avancée considérable pour augmenter la productivité et écologiser l'industrie chimique.