WO2026142524 - AMORPHOUS FORM OF CABOZANTINIB SULFATE MONOHYDRATE AND METHOD OF PREPARATION

National phase entry is expected:
Publication Number WO/2026/142524
Publication Date 02.07.2026
International Application No. PCT/TR2024/051737
International Filing Date 25.12.2024
Title **
[English] AMORPHOUS FORM OF CABOZANTINIB SULFATE MONOHYDRATE AND METHOD OF PREPARATION
[French] FORME AMORPHE DE SULFATE DE CABOZANTINIB MONOHYDRATÉ ET PROCÉDÉ DE PRÉPARATION
Applicants **
DEVA HOLDING
Inventors
HAAS, Philipp Daniel
STECKEL, Hartwig Andreas
BELLUR ATİCİ, Esen
KESKİN, Elif
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Quotation for National Phase entry

Country StagesTotal
China Filing, Examination, Granting1897
EPO Filing, Examination, Granting8986
Japan Filing, Examination, Granting1964
South Korea Filing, Examination, Granting1544
USA Filing, Examination, Granting6540
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Total: 20,931
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Abstract[English] The present invention refers to an amorphous form of cabozantinib sulphate monohydrate and a process for its preparation, a pharmaceutical composition comprising it, and its use for the the treatment of patients with progressive, metastatic medullary thyroid cancer (MTC) and for the treatment of patients with advanced renal cell carcinoma (RCC) who have received prior antiangiogenic therapy treatment of cancer.[French] La présente invention concerne une forme amorphe de sulfate de cabozantinib monohydraté et un procédé pour sa préparation, une composition pharmaceutique la comprenant, et son utilisation pour le traitement de patients atteints d'un cancer médullaire de la thyroïde (CMT) progressif et métastatique et pour le traitement de patients atteints d'un carcinome rénal à cellules claires (CRCC) avancé ayant reçu un traitement antérieur par thérapie antiangiogénique.