WO2023140809 - NOVEL POLYMORPH OF VISMODEGIB AND METHOD OF PREPARATION
National phase entry:
Publication Number
WO/2023/140809
Publication Date
27.07.2023
International Application No.
PCT/TR2022/050047
International Filing Date
20.01.2022
Title **
[English]
NOVEL POLYMORPH OF VISMODEGIB AND METHOD OF PREPARATION
[French]
NOUVEAU POLYMORPHE DE VISMODÉGIB ET PROCÉDÉ DE PRÉPARATION
Applicants **
DEVA HOLDING
Halkali Merkez Mah. Basin Ekspres Cad. No:1
34303 Kucukcekmece/Istanbul, TR
Inventors
HAAS, Philipp Daniel
Halkali Merkez Mah. Basin Ekspres Cad. No:1
34303 Kucukcekmece/Istanbul, TR
STECKEL, Hartwig Andreas
Halkali Merkez Mah. Basin Ekspres Cad. No:1
34303 Kucukcekmece/Istanbul, TR
BELLUR ATİCİ, Esen
Halkali Merkez Mah. Basin Ekspres Cad. No:1
34303 Kucukcekmece/Istanbul, TR
BAŞLAR, Yıldıray
Halkali Merkez Mah. Basin Ekspres Cad. No:1
34303 Kucukcekmece/Istanbul, TR
KESKİN, Elif
Halkali Merkez Mah. Basin Ekspres Cad. No:1
34303 Kucukcekmece/Istanbul, TR
Application details
| Total Number of Claims/PCT | * |
| Number of Independent Claims | * |
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| Number of Multi-Dependent Claims | * |
| Number of Drawings | * |
| Pages for Publication | * |
| Number of Pages with Drawings | * |
| Pages of Specification | * |
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International Searching Authority |
Turkpatent
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| Applicant's Legal Status |
Legal Entity
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| Entry into National Phase under |
Chapter I
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| Translation |
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Quotation for National Phase entry
| Country | Stages | Total | |
|---|---|---|---|
| China | Filing | 891 | |
| EPO | Filing, Examination | 4834 | |
| Japan | Filing | 588 | |
| South Korea | Filing | 481 | |
| USA | Filing, Examination | 2710 |
Total: 9504 USD
The term for entry into the National Phase has expired. This quotation is for informational purposes only
Abstract[English]
The present invention relates to a new crystalline form of vismodegib, a methanol-solvate of vismodegib, namely Form S, and methods for its preparation. The vismodegib Form S is characterized by an XRPD pattern having characteristic peaks (2theta ± 0.2º) at 7.1, 14.0, 16.7, 19.1, 22.3, 24.6 and 28.0. The present invention also provides interconversion process of vismodegib Form S to crystalline vismodegib Form B, pharmaceutical compositions comprising vismodegib Form S, and medical use of vismodegib Form S.[French]
La présente invention concerne une nouvelle forme cristalline de vismodégib, un solvate de méthanol de vismodégib, à savoir la forme S, ainsi que des procédés pour sa préparation. La forme S de vismodégib est caractérisée par un diagramme XRPD ayant des pics caractéristiques (2 thêta ± 0,2°) à 7,1, 14,0, 16,7, 19,1, 22,3, 24,6 et 28,0. La présente invention concerne également un procédé d'interconversion de forme S de vismodégib en forme B de vismodégib cristalline, des compositions pharmaceutiques comprenant une forme S de vismodégib, et une utilisation médicale de la forme S de vismodégib.