WO2026094064 - PROCESS FOR THE SYNTHESIS OF INTERMEDIATE COMPOUNDS USEFUL FOR THE PREPARATION OF GALNAC (L96) CONJUGATED OLIGONUCLEOTIDES

National phase entry is expected:
Publication Number WO/2026/094064
Publication Date 07.05.2026
International Application No. PCT/IN2025/051691
International Filing Date 22.10.2025
Title **
[English] PROCESS FOR THE SYNTHESIS OF INTERMEDIATE COMPOUNDS USEFUL FOR THE PREPARATION OF GALNAC (L96) CONJUGATED OLIGONUCLEOTIDES
[French] PROCÉDÉ POUR LA SYNTHÈSE DE COMPOSÉS INTERMÉDIAIRES UTILES POUR LA PRÉPARATION D'OLIGONUCLÉOTIDES CONJUGUÉS DE GALNAC (L96)
Applicants **
NATCO PHARMA LIMITED
Inventors
KAPARAPU, Phaneendra
AWACHAT, Ragini Raghuvir
SABALE, Pramod Madhavrao
MUDDASANI, Pulla Reddy
NANNAPANENI, Venkaiah Chowdary
Priority Data
202441083201   30.10.2024   IN
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Quotation for National Phase entry

Country StagesTotal
China Filing, Examination, Granting1956
EPO Filing, Examination, Granting11576
Japan Filing, Examination, Granting2001
South Korea Filing, Examination, Granting1805
USA Filing, Examination, Granting4740
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Total: 22,078
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Abstract[English] The present invention relates to a simple and cost-effective improved process for the preparation of GalNAc (L96) conjugated oligonucleotides. The present invention relates to a simple and cost-effective improved process for the preparation of intermediate of GalNAc (L96) conjugated oligonucleotides compound of Formulae-(I) & (Ia). Formula-(I) Formula-(Ia)[French] La présente invention concerne un procédé amélioré, simple et économique pour la préparation d'oligonucléotides conjugués GalNAc (L96). La présente invention concerne un procédé amélioré, simple et économique pour la préparation d'un intermédiaire de composé d'oligonucléotides conjugués GalNAc (L96) de formules-(I) et (Ia). Formule-(I), Formule-(Ia)