WO2024194884 - PREPARATION AND PHARMACEUTICAL APPLICATION OF A NOVEL PENTACYCLIC TRITERPENOID

National phase entry is expected:
Publication Number WO/2024/194884
Publication Date 26.09.2024
International Application No. PCT/IN2024/050255
International Filing Date 12.03.2024
Title **
[English] PREPARATION AND PHARMACEUTICAL APPLICATION OF A NOVEL PENTACYCLIC TRITERPENOID
[French] PRÉPARATION ET APPLICATION PHARMACEUTIQUE D'UN NOUVEAU TRITERPÉNOÏDE PENTACYCLIQUE
Applicants **
SUTHAR, Sharad Kumar
Inventors
MONGA, Jitender
Priority Data
202321019822   22.03.2023   IN
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Quotation for National Phase entry

Country StagesTotal
China Filing, Examination, Granting1958
EPO Filing, Examination, Granting8900
Japan Filing, Examination, Granting1864
South Korea Filing, Examination, Granting1392
USA Filing, Examination, Granting4740
MasterCard Visa
Total: 18,854

The term for entry into the National Phase has expired. This quotation is for informational purposes only

Abstract[English] LA; 2-methylene-3-oxo-226-angeloyloxy-olean-12-en-28-oic acid) was developed from Lantadene A (LA). The newly developed compound displayed potent cytotoxicity against cancer cell lines, with highly cytotoxic to kidney and prostate cancer cell lines. The biological data of the compound indicates the potential pharmaceutical use of the compound in cancer, inflammation, and oxidative stress-associated inflammation and injuries, for example, autoimmune diseases, renal inflammation and injury, and eye inflammation and injury.[French] Un nouveau triterpénoïde pentacyclique de la série oléanane appelé composé de formule I (2CH2LA ; acide 2-méthylène-3-oxo-22β-angéloyloxy-oléan-12-én-28-oïque) a été développé à partir du lantadène A (LA). Le composé nouvellement développé présente une cytotoxicité puissante contre des lignées cellulaires cancéreuses, avec une haute cytotoxicité vis-à-vis de lignées cellulaires de cancer de la prostate et des reins. Les données biologiques du composé indiquent l'utilisation pharmaceutique potentielle du composé dans le cancer, l'inflammation ainsi que l'inflammation et les lésions associées au stress oxydatif, par exemple, des maladies auto-immunes, l'inflammation et les lésions rénales, ainsi que l'inflammation et les lésions oculaires.

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