WO2024231938 - BENZALKONIUM CHLORIDE FREE OPHTHALMIC FORMULATION

National phase entry:
Publication Number WO/2024/231938
Publication Date 14.11.2024
International Application No. PCT/IN2023/051120
International Filing Date 30.11.2023
Title **
[English] BENZALKONIUM CHLORIDE FREE OPHTHALMIC FORMULATION
[French] FORMULATION OPHTALMIQUE EXEMPTE DE CHLORURE DE BENZALKONIUM
Applicants **
AKUMS DRUGS & PHARMACEUTICALS LIMITED 304, Mohan Place, L.S.C. Block-C, Saraswati Vihar Delhi 110034, IN
Inventors
JAIN, Sanjeev Akums Drugs & Pharmaceuticals Limited 304, Mohan Place, LSC, Block-C, Saraswati Vihar Delhi 110034, IN
GOSWAMI, Manoj Akums Drugs & Pharmaceuticals Ltd. 304, Mohan Place, LSC, Block-C, Saraswati Vihar Delhi 110034, IN
MODI, Manu Akums Drugs & Pharmaceuticals Ltd. 304, Mohan Place, LSC, Block-C, Saraswati Vihar Delhi 110034, IN
Priority Data
202311033469   11.05.2023   IN
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Quotation for National Phase entry

Country StagesTotal
China Filing1049
EPO Filing, Examination6635
Japan Filing594
South Korea Filing575
USA Filing, Examination3910
MasterCard Visa

Total: 12763

The term for entry into the National Phase has expired. This quotation is for informational purposes only

Abstract[English] The present invention provides an ophthalmic composition comprising fixed dose combinations of carbonic anhydrase inhibitor(s) and alpha-2-adrenergic agonist(s) wherein the composition is free of benzalkonium chloride (BAK). The ophthalmic composition of the present invention provides a stable aqueous ophthalmic composition comprising fixed dose combination of Brinzolamide and Brimonidine tartate preserved with synergistic combination of EDTA, mannitol, borate and zinc or salts thereof to preserve the composition against microbial growth.[French] La présente invention concerne une composition ophtalmique comprenant des combinaisons de doses fixes d'inhibiteur(s) d'anhydrase carbonique et d'agoniste(s) alpha-2-adrénergique, la composition étant exempte de chlorure de benzalkonium (BAK). La composition ophtalmique de la présente invention fournit une composition ophtalmique aqueuse stable comprenant une combinaison de doses fixes de Brinzolamide et de tartate de Brimonidine conservée avec une combinaison synergique d'EDTA, de mannitol, de borate et de zinc ou de sels de celui-ci pour préserver la composition contre la croissance microbienne.
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