WO2025012904 - GENETICALLY ENGINEERED PLACENTAL MUCOSAL-ASSOCIATED INVARIANT T (MAIT) CELLS AND USES THEREOF
National phase entry:
Publication Number
WO/2025/012904
Publication Date
16.01.2025
International Application No.
PCT/IL2024/050675
International Filing Date
09.07.2024
Title **
[English]
GENETICALLY ENGINEERED PLACENTAL MUCOSAL-ASSOCIATED INVARIANT T (MAIT) CELLS AND USES THEREOF
[French]
LYMPHOCYTES T INVARIANTS ASSOCIÉS AUX MUQUEUSES PLACENTAIRES GÉNÉTIQUEMENT MODIFIÉES ET UTILISATIONS ASSOCIÉES
Applicants **
PLURI BIOTECH LTD.
MATAM PARK, BUILDING 05
3508409 HAIFA, IL
Inventors
MACHLENKIN, Arthur
BEN GEFEN 80
7044730 GEDERA, IL
SHARBI-YUNGER, Adi
TIROSH 42
6081688 SHOHAM, IL
ISH SHALOM, Eliran
1913200 KIBBUTZ TEL YOSEF, IL
SHAKED, Helena Lea
HASHALOM 20
4356120 RAANANA, IL
Priority Data
63/525,836
10.07.2023
US
Application details
| Total Number of Claims/PCT | * |
| Number of Independent Claims | * |
| Number of Priorities | * |
| Number of Multi-Dependent Claims | * |
| Number of Drawings | * |
| Pages for Publication | * |
| Number of Pages with Drawings | * |
| Pages of Specification | * |
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International Searching Authority |
ILPO
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| Applicant's Legal Status |
Legal Entity
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| Entry into National Phase under |
Chapter I
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| Translation |
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Recalculate
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Quotation for National Phase entry
| Country | Stages | Total | |
|---|---|---|---|
| China | Filing | 2974 | |
| EPO | Filing, Examination | 25935 | |
| Japan | Filing | 587 | |
| South Korea | Filing | 574 | |
| USA | Filing, Examination | 14960 |
Total: 45030 USD
The term for entry into the National Phase has expired. This quotation is for informational purposes only
Abstract[English]
This invention is directed in one main aspect to a cell composition comprising a population of engineered mucosal-associated invariant T (MAIT) cells derived from placental tissue expressing an exogenous chimeric antigen receptor (CAR). The invention further discloses a unique placental MAIT cell population, cell compositions comprising the MAIT cell population, and methods of use.[French]
La présente invention concerne, selon un aspect principal, une composition cellulaire comprenant une population de lymphocytes T invariants associés aux muqueuses (MAIT, « mucosal-associated invariant T cell ») modifiés dérivés d'un tissu placentaire exprimant un récepteur antigénique chimérique (CAR) exogène. L'invention concerne en outre une population de cellules MAIT placentaires uniques, des compositions cellulaires comprenant la population de cellules MAIT, ainsi que des procédés d'utilisation.