WO2024252382 - A SYSTEM FOR 3D CULTIVATION OF PLANT CELLS AND METHODS OF USE
National phase entry is expected:
Publication Number
WO/2024/252382
Publication Date
12.12.2024
International Application No.
PCT/IL2024/050278
International Filing Date
18.03.2024
Title **
[English]
A SYSTEM FOR 3D CULTIVATION OF PLANT CELLS AND METHODS OF USE
[French]
SYSTÈME DE CULTURE 3D DE CELLULES VÉGÉTALES ET PROCÉDÉS D'UTILISATION
Applicants **
PLURI BIOTECH LTD.
Matam Park
Building 05
3508409 HAIFA, IL
Inventors
RAVIV, Lior
122 Tractor Road
4287500 Kfar Monash, IL
BEN ELIEZER, Eran
Fish Brothers Lane 11
3602511 Kiryat Tivon, IL
Priority Data
303555
08.06.2023
IL
Application details
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International Searching Authority |
ILPO
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| Applicant's Legal Status |
Legal Entity
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| Entry into National Phase under |
Chapter I
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| Translation |
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Recalculate
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Quotation for National Phase entry
| Country | Stages | Total | |
|---|---|---|---|
| China | Filing | 1387 | |
| EPO | Filing, Examination | 9299 | |
| Japan | Filing | 526 | |
| South Korea | Filing | 575 | |
| USA | Filing, Examination | 3835 |
Total: 15622 USD
Abstract[English]
This invention is directed to a method for three-dimensional cultivation of proliferating plant cells in a packed bed bioreactor, the bioreactor comprising at least one packed bed chamber configured to confine said proliferating plant cells within it such that the proliferating plant cells become a three-dimensional stationary biomass phase; and At least one container comprising a fluid media, the fluid media is configured to flow through said proliferating plant cells stationary biomass phase, wherein, the flow of the fluid media through the proliferating plant cells stationary biomass phase allows transfer of compounds from the fluid media into the cells and vice versa in low shear forces within the at least one packed bed chamber thereby imitating natural growth environment of the proliferating plant cells within the 3D bioreactor.[French]
La présente invention concerne un procédé de culture 3D de cellules végétales proliférantes dans un bioréacteur à lit fixe, le bioréacteur contenant au moins une chambre à lit fixe conçue pour confiner lesdites cellules végétales proliférantes en son sein de sorte que les cellules végétales proliférantes se transforment en une phase de biomasse stationnaire 3D ; et au moins un récipient contenant un milieu fluide, le milieu fluide étant conçu pour s'écouler à travers ladite phase de biomasse stationnaire des cellules végétales proliférantes, l'écoulement du milieu fluide à travers la phase de biomasse stationnaire des cellules végétales proliférantes permettant le transfert de composés du milieu fluide dans les cellules et vice versa avec de faibles forces de cisaillement à l'intérieur de ladite au moins une chambre à lit fixe, imitant ainsi l'environnement de croissance naturel des cellules végétales proliférantes à l'intérieur du bioréacteur 3D.