WO2026120558 - MACROCYCLIC COMPOUNDS AS ATM INHIBITORS

National phase entry is expected:
Publication Number WO/2026/120558
Publication Date 11.06.2026
International Application No. PCT/IB2025/062490
International Filing Date 05.12.2025
Title **
[English] MACROCYCLIC COMPOUNDS AS ATM INHIBITORS
[French] COMPOSÉS MACROCYCLIQUES EN TANT QU'INHIBITEURS DE L'ATM
Applicants **
SUN PHARMA ADVANCED RESEARCH COMPANY LIMITED
Inventors
KARCHE, Navnath P.
CHIMANWALA, Sabbirhusen Y.
BHUNIYA, Debnath
PALLE, Venkata P.
Priority Data
202421096506   06.12.2024   IN
202521066597   12.07.2025   IN
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Quotation for National Phase entry

Country StagesTotal
China Filing, Examination, Granting3798
EPO Filing, Examination, Granting23231
Japan Filing, Examination, Granting2803
South Korea Filing, Examination, Granting3424
USA Filing, Examination, Granting14840
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Total: 48,096
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Abstract[English] The present disclosure relates to macrocyclic compounds as potent Ataxia-Telangiectasia Mutated (ATM) inhibitors, their tautomers, stereoisomers, pharmaceutically acceptable salts, hydrates, solvates, isotopes, prodrugs and N-oxides. The present disclosure also relates to the processes for their preparation, their compositions, their combination with suitable medicament and their use for the treatment of diseases modulated by ATM kinase.[French] La présente divulgation concerne des composés macrocycliques en tant que puissants inhibiteurs de l'Ataxia-Telangiectasia Mutated (ATM), leurs tautomères, stéréoisomères, sels pharmaceutiquement acceptables, hydrates, solvates, isotopes, promédicaments et N-oxydes. La présente divulgation concerne également les procédés de préparation de ces composés, leurs compositions, leur combinaison avec un médicament approprié et leur utilisation pour le traitement de maladies modulées par la kinase ATM.