WO2026110120 - DOUBLE STRANDED RNAI AGENTS, COMPOSITIONS AND METHODS OF USE

National phase entry is expected:
Publication Number WO/2026/110120
Publication Date 28.05.2026
International Application No. PCT/IB2025/062014
International Filing Date 24.11.2025
Title **
[English] DOUBLE STRANDED RNAI AGENTS, COMPOSITIONS AND METHODS OF USE
[French] AGENTS ARNI DOUBLE BRIN, COMPOSITIONS ET PROCÉDÉS D'UTILISATION
Applicants **
NOVARTIS AG
Inventors
HUNZIKER, Juerg
Priority Data
63/724,676   25.11.2024   US
63/841,428   10.07.2025   US
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Quotation for National Phase entry

Country StagesTotal
China Filing, Examination, Granting6457
EPO Filing, Examination, Granting95750
Japan Filing, Examination, Granting4742
South Korea Filing, Examination, Granting7383
USA Filing, Examination, Granting33740
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Total: 148,072
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Abstract[English] Disclosed are, inter alia, therapeutic dsRNAi agents with at least one TNA clamp on the sense strand for use in silencing a target gene in a cell or in a subject.[French] La présente invention concerne, entre autres, des agents thérapeutiques de type ARNi double brin (ARNidb)comportant au moins une pince TNA sur le brin sens, destinés à être utilisés pour le silençage d'un gène cible dans une cellule ou chez un sujet.