WO2026047608 - METHODS RELATED TO MULTIPLE MYELOMA AND PRECURSORS THEREOF

National phase entry is expected:
Publication Number WO/2026/047608
Publication Date 05.03.2026
International Application No. PCT/IB2025/058719
International Filing Date 29.08.2025
Title **
[English] METHODS RELATED TO MULTIPLE MYELOMA AND PRECURSORS THEREOF
[French] PROCÉDÉS ASSOCIÉS À UN MYÉLOME MULTIPLE ET PRÉCURSEURS ASSOCIÉS
Applicants **
DANA-FARBER CANCER INSTITUTE, INC.
THE GENERAL HOSPITAL CORPORATION
Inventors
SKLAVENITIS PISTOFIDIS, Romanos
GETZ, Gad
GHOBRIAL, Irene
Priority Data
63/689,201   30.08.2024   US
63/698,902   25.09.2024   US
63/715,843   04.11.2024   US
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Quotation for National Phase entry

Country StagesTotal
China Filing, Examination, Granting3695
EPO Filing, Examination, Granting26993
Japan Filing, Examination, Granting3140
South Korea Filing, Examination, Granting4136
USA Filing, Examination, Granting14790
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Total: 52,754
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Abstract[English] Disclosed herein are differences in the features of immune cell populations in subjects with monoclonal gammopathy of unknown significance (MGUS) or smoldering myeloma (SMM), compared to subjects with multiple myeloma (MM). These features are useful in methods for monitoring progression from MGUS or SMM to MM in a subject. In some instances, certain features are also useful in methods for predicting the response of a subject's MM to therapy.[French] L'invention concerne des différences dans les caractéristiques de populations de cellules immunitaires chez des sujets atteints d'une gammopathie monoclonale de signification indéterminée (GMSI) ou de myélome multiple indolent (MMI), par comparaison avec des sujets atteints de myélome multiple (MM). Ces caractéristiques sont utiles dans des procédés de surveillance de la progression de GMSI ou de MMI à MM chez un sujet. Dans certains cas, certaines caractéristiques sont également utiles dans des procédés de prédiction de la réponse du MM d'un sujet à une thérapie.