WO2026022677 - PERMANENTLY CHARGED CATIONIC LIPIDS
National phase entry is expected:
Publication Number
WO/2026/022677
Publication Date
29.01.2026
International Application No.
PCT/IB2025/057375
International Filing Date
22.07.2025
Title **
[English]
PERMANENTLY CHARGED CATIONIC LIPIDS
[French]
LIPIDES CATIONIQUES CHARGÉS EN PERMANENCE
Applicants **
GENEVANT SCIENCES GMBH
Inventors
HOLLAND, Richard James
WOOD, Mark Christopher
LAM, Kieu
ZHANG, Wenxuan
REID, Stephen
Priority Data
63/673,928
22.07.2024
US
Application details
| Total Number of Claims/PCT | * |
| Number of Independent Claims | * |
| Number of Priorities | * |
| Number of Multi-Dependent Claims | * |
| Number of Drawings | * |
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| Number of Pages with Drawings | * |
| Pages of Specification | * |
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International Searching Authority |
EPO
* |
| Recordal of a Change of the Applicant's Name/Address |
Change of Applicant's Name and Address
* |
| Type of Assignment |
The Standard Agent's Assignment
* |
| Applicant's Legal Status |
Legal Entity
* |
| * | |
| * | |
| * | |
| * | |
| * | |
| Entry into National Phase under |
Chapter I
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| Patent Delivery |
Send the Letters Patent by Courier
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| Translation |
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* The data is based on automatic recognition. Please verify and amend if necessary.
** IP-Coster compiles data from publicly available sources. If this data includes your personal information, you can contact us to request its removal.
Quotation for National Phase entry
| Country | Stages | Total | |
|---|---|---|---|
| China | Filing, Examination, Granting | 4990 | |
| EPO | Filing, Examination, Granting | 75278 | |
| Japan | Filing, Examination, Granting | 4410 | |
| South Korea | Filing, Examination, Granting | 6273 | |
| USA | Filing, Examination, Granting | 25240 |
Total:
116,191
Abstract[English]
The present disclosure provides permanently charged cationic lipids that are particularly beneficial in formulations of lipid nanoparticles providing advantageous improvements in the delivery of nucleic acids to hepatic stellate cells with enhanced efficiency. The permanently charged cationic lipids are quaternary ammonium lipids that are silyl ethers. The disclosure also provides lipid nanoparticle, pharmaceutical compositions, and methods including the provided permanently charged cationic lipids.[French]
La présente divulgation concerne des lipides cationiques chargés en permanence qui sont particulièrement avantageux dans des formulations de nanoparticules lipidiques fournissant des améliorations avantageuses dans l'administration d'acides nucléiques à des cellules stellaires hépatiques avec une efficacité améliorée. Les lipides cationiques chargés en permanence sont des lipides d'ammonium quaternaire qui sont des éthers de silyle. La divulgation concerne également des nanoparticules lipidiques, des compositions pharmaceutiques et des procédés comprenant les lipides cationiques chargés en permanence divulgués.