WO2026018205 - SYSTEM AND METHODS FOR GENERATING A HYBRID MODEL-BASED DIGITAL SIMULATOR (HMBDS) THAT SIMULATES BIOPROCESSES IN A REAL-WORLD CELL CULTURE CONTAINER
National phase entry is expected:
Publication Number
WO/2026/018205
Publication Date
22.01.2026
International Application No.
PCT/IB2025/057274
International Filing Date
17.07.2025
Title **
[English]
SYSTEM AND METHODS FOR GENERATING A HYBRID MODEL-BASED DIGITAL SIMULATOR (HMBDS) THAT SIMULATES BIOPROCESSES IN A REAL-WORLD CELL CULTURE CONTAINER
[French]
SYSTÈME ET PROCÉDÉS POUR GÉNÉRER UN SIMULATEUR NUMÉRIQUE HYBRIDE BASÉ SUR UN MODÈLE (HMBDS) QUI SIMULE DES BIOPROCESSUS DANS UN RÉCIPIENT DE CULTURE CELLULAIRE RÉEL
Applicants **
C/O ALGOCELL LTD
Inventors
BETZALEL, Eyal
SCHANIN, Omri Nadav
Priority Data
63/673,038
18.07.2024
US
Application details
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International Searching Authority |
ILPO
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| Recordal of a Change of the Applicant's Name/Address |
Change of Applicant's Name and Address
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| Type of Assignment |
The Standard Agent's Assignment
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| Applicant's Legal Status |
Legal Entity
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| Entry into National Phase under |
Chapter I
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| Patent Delivery |
Send the Letters Patent by Courier
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Quotation for National Phase entry
| Country | Stages | Total | |
|---|---|---|---|
| China | Filing, Examination, Granting | 2276 | |
| EPO | Filing, Examination, Granting | 14610 | |
| Japan | Filing, Examination, Granting | 2339 | |
| South Korea | Filing, Examination, Granting | 2529 | |
| USA | Filing, Examination, Granting | 4940 |
Total:
26,694
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Abstract[English]
A method for generating a hybrid model based digital simulator (HMBDS) that simulates at least one bioprocess that executing in a real-world cell culture container, comprising: receiving a model of a first bioprocess; receiving a plurality of experimental results data of the first bioprocess in the real-world cell culture container; generating a HMBDS based on the received first bioprocess model, the real-world cell culture container, and the received experimental results data; performing a simulation of a bioprocess executing within the real-world cell culture container using the HMBDS; performing optimization of the bioprocess based on the results of the simulation; and causing execution of the optimized bioprocess by the at least a first real-world cell culture container.[French]
Procédé pour générer un simulateur numérique hybride basé sur un modèle (HMBDS) qui simule au moins un bioprocessus s'exécutant dans un récipient de culture cellulaire réel, comportant les étapes suivantes : réception d'un modèle d'un premier bioprocessus; obtention d'une pluralité de données de résultats expérimentaux du premier bioprocessus dans le récipient de culture cellulaire réel; génération d'un HMBDS basé sur le modèle de premier bioprocessus, le récipient de culture cellulaire réel et les données expérimentales reçus; exécution d'une simulation d'un bioprocessus s'exécutant dans le récipient de culture cellulaire réel à l'aide du HMBDS; optimisation du bioprocessus sur la base des résultats de la simulation; et exécution du bioprocessus optimisé par au moins un premier récipient de culture cellulaire réel.