WO2025238578 - GUIDE RNAS FOR ALLELE-SELECTIVE GENE EDITING, AND COMPOSITIONS AND METHODS RELATING THERETO
National phase entry is expected:
Publication Number
WO/2025/238578
Publication Date
20.11.2025
International Application No.
PCT/IB2025/055061
International Filing Date
14.05.2025
Title **
[English]
GUIDE RNAS FOR ALLELE-SELECTIVE GENE EDITING, AND COMPOSITIONS AND METHODS RELATING THERETO
[French]
ARN GUIDE POUR L'ÉDITION GÉNÉTIQUE SÉLECTIVE D'ALLÈLES, COMPOSITIONS ET PROCÉDÉS ASSOCIÉS
Applicants **
INCISIVE GENETICS, INC.
THE UNIVERSITY OF BRITISH COLUMBIA
Inventors
CARON, Nicholas
CAPRON, Arnaud
HILL, Austin
WAGNER, Pamela
LEAVITT, Blair
CHENG, Jung-Chien
LIU, Yaxin
YI, Yuyin
Priority Data
63/647,377
14.05.2024
US
63/680,656
08.08.2024
US
Application details
| Total Number of Claims/PCT | * |
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International Searching Authority |
CIPO
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| Recordal of a Change of the Applicant's Name/Address |
Change of Applicant's Name and Address
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| Type of Assignment |
The Standard Agent's Assignment
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| Applicant's Legal Status |
Legal Entity
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| * | |
| * | |
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| Entry into National Phase under |
Chapter I
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| Patent Delivery |
Send the Letters Patent by Courier
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| Translation |
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* The data is based on automatic recognition. Please verify and amend if necessary.
** IP-Coster compiles data from publicly available sources. If this data includes your personal information, you can contact us to request its removal.
Quotation for National Phase entry
| Country | Stages | Total | |
|---|---|---|---|
| China | Filing, Examination, Granting | 3884 | |
| EPO | Filing, Examination, Granting | 22042 | |
| Japan | Filing, Examination, Granting | 2431 | |
| South Korea | Filing, Examination, Granting | 2768 | |
| USA | Filing, Examination, Granting | 10490 |
Total:
41,615
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Abstract[English]
The present disclosure provides gRNAs for allele-selective gene editing, nucleic acids encoding such a gRNA, vectors comprising such a nucleic acid, RNPs comprising such a gRNA and a Cas protein, pharmaceutical compositions comprising any of the foregoing, and kits comprising any of the foregoing. The present disclosure further provides methods related to such gRNAs, including methods of manufacturing, methods of effecting allele-selective gene editing, and methods of preventing, treating, or ameliorating a symptom of a target disease, disorder, or condition using such gRNAs. The present disclosure further provides lipid-based TCVs.[French]
La présente invention concerne des ARNg pour l'édition génétique sélective d'allèles, des acides nucléiques codant pour un tel ARNg, des vecteurs comportant un tel acide nucléique, des RNP comportant un tel ARNg et une protéine Cas, des compositions pharmaceutiques comportant l'un quelconque des éléments précités, et des kits comportant l'un quelconque des éléments précités. La présente invention concerne également des procédés liés à ces ARNg, notamment des procédés de fabrication, des procédés permettant d'effectuer une édition génétique sélective des allèles, et des procédés permettant de prévenir, traiter ou atténuer un symptôme d'une maladie, d'un trouble ou d'une pathologie cible à l'aide de ces ARNg. La présente invention concerne également des TCV à base de lipides.