WO2025233858 - GEOMETRICALLY ENHANCED LATERAL FLOW IMMUNOASSAYS FOR QUANTITATIVE ASSESSMENT OF BIOMARKERS IN POINT-OF-NEED APPLICATIONS
National phase entry is expected:
Publication Number
WO/2025/233858
Publication Date
13.11.2025
International Application No.
PCT/IB2025/054792
International Filing Date
07.05.2025
Title **
[English]
GEOMETRICALLY ENHANCED LATERAL FLOW IMMUNOASSAYS FOR QUANTITATIVE ASSESSMENT OF BIOMARKERS IN POINT-OF-NEED APPLICATIONS
[French]
DOSAGES IMMUNOLOGIQUES À FLUX LATÉRAL AMÉLIORÉS GÉOMÉTRIQUEMENT POUR L'ÉVALUATION QUANTITATIVE DE BIOMARQUEURS DANS DES APPLICATIONS AU POINT D'INTERVENTION
Applicants **
1469694 B.C. LTD.
Inventors
SALAHANDISH, Razieh
HAGHAYEGH, Fatemeh
RAICHURA, Ashissh
HAGHANI, Elnaz
NOROUZIAZAD, Alireza
Priority Data
63/643,523
07.05.2024
US
Application details
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International Searching Authority |
CIPO
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| Recordal of a Change of the Applicant's Name/Address |
Change of Applicant's Name and Address
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| Type of Assignment |
The Standard Agent's Assignment
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| Applicant's Legal Status |
Legal Entity
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| Entry into National Phase under |
Chapter I
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| Patent Delivery |
Send the Letters Patent by Courier
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| Translation |
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* The data is based on automatic recognition. Please verify and amend if necessary.
** IP-Coster compiles data from publicly available sources. If this data includes your personal information, you can contact us to request its removal.
Quotation for National Phase entry
| Country | Stages | Total | |
|---|---|---|---|
| China | Filing, Examination, Granting | 2308 | |
| EPO | Filing, Examination, Granting | 14369 | |
| Japan | Filing, Examination, Granting | 2307 | |
| South Korea | Filing, Examination, Granting | 2463 | |
| USA | Filing, Examination, Granting | 7140 |
Total:
28,587
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Abstract[English]
Lateral flow immunoassay systems include test strips having unique geometries to enhance fluid dynamics, including but not limited to: (1) conjugate pads having sinusoidal, meandering, and nozzle-diffuser patterns; and (2) nitrocellulose membrane pads having constriction zones corresponding to the location of T-lines and/or C-lines. The systems can further include a cartridge with a two-step rotation mechanism for contamination-free sample delivery to the sample pad of a test strip, and an AI-based detection system for quantifying the concentration of a detected analyte based on colorimetric signal intensities. The system exhibits improved analyte sensitivity over prior systems, reduces traditional assay time, eliminates subjective interpretation of colorimetric signal intensities, and quantifies analyte concentration levels.[French]
Les systèmes de dosage immunologique à flux latéral comprennent des bandelettes réactives ayant des géométries uniques destinées à améliorer la dynamique des fluides, comprenant, mais sans s'y limiter : (1) des tampons de conjugués ayant des motifs sinusoïdaux, sinueux et de diffuseur à buse ; et (2) des tampons de membrane de nitrocellulose ayant des zones de constriction correspondant à l'emplacement de lignes T et/ou de lignes C. Les systèmes peuvent en outre comprendre une cartouche ayant un mécanisme de rotation en deux étapes qui permet la distribution sans contamination d'un échantillon au tampon d'échantillon d'une bandelette réactive, et un système de détection reposant sur l'IA qui quantifie la concentration d'un analyte détecté sur la base d'intensités de signal colorimétrique. Le système offre une sensibilité à l'analyte améliorée par rapport aux systèmes antérieurs, réduit le temps de dosage classique, élimine l'interprétation subjective des intensités de signal colorimétrique, et quantifie les niveaux de concentration d'analyte.