WO2025219869 - METHODS OF PURIFYING IMMUNOGLOBULINS COMPRISING N-TERMINAL GLUTAMINE
National phase entry is expected:
Publication Number
WO/2025/219869
Publication Date
23.10.2025
International Application No.
PCT/IB2025/053923
International Filing Date
15.04.2025
Title **
[English]
METHODS OF PURIFYING IMMUNOGLOBULINS COMPRISING N-TERMINAL GLUTAMINE
[French]
PROCÉDÉS DE PURIFICATION D'IMMUNOGLOBULINES COMPRENANT DE LA GLUTAMINE À EXTRÉMITÉ N-TERMINALE
Applicants **
RICHTER GEDEON NYRT.
Inventors
SÜTŐ, Zoltán
VÁSÁRHELYI, Viktor Sándor
TAR, Balázs
Priority Data
P2400216
17.04.2024
HU
Application details
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International Searching Authority |
EPO
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| Recordal of a Change of the Applicant's Name/Address |
Change of Applicant's Name and Address
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| Type of Assignment |
The Standard Agent's Assignment
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| Applicant's Legal Status |
Legal Entity
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| Entry into National Phase under |
Chapter I
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| Patent Delivery |
Send the Letters Patent by Courier
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| Translation |
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Quotation for National Phase entry
| Country | Stages | Total | |
|---|---|---|---|
| China | Filing, Examination, Granting | 2628 | |
| EPO | Filing, Examination, Granting | 13533 | |
| Japan | Filing, Examination, Granting | 2422 | |
| South Korea | Filing, Examination, Granting | 2454 | |
| USA | Filing, Examination, Granting | 5140 |
Total:
26,177
Abstract[English]
The present invention relates to a method for the purification of immunoglobulins comprising N- terminal glutamine. In particular, the method comprises an incubation step embedded in a sequence of chromatographic methods comprising a capture step, an intermediate chromatography step, and a polishing step. The implementation of an incubation step embedded in the sequence of chromatographic purification methods promotes the conversion of N-terminal glutamine to pyro glutamate, thereby reducing the amount of N-terminal glutamine to be depleted by cation exchange chromatography while overall product yield is increased. In addition, the incubation may be conducted prior or following the intermediate chromatography step.[French]
La présente invention concerne un procédé de purification d'immunoglobulines comprenant de la glutamine à extrémité N-terminale. En particulier, le procédé comprend une étape d'incubation incorporée dans une séquence de procédés chromatographiques comprenant une étape de capture, une étape de chromatographie intermédiaire et une étape de polissage. La mise en oeuvre d'une étape d'incubation incorporée dans la séquence de procédés de purification chromatographique favorise la conversion de glutamine à extrémité N-terminale en pyro glutamate, ce qui permet de réduire la quantité de glutamine à extrémité N-terminale à appauvrir par chromatographie d'échange de cations tout en augmentant le rendement global du produit. De plus, l'incubation peut être effectuée avant ou après l'étape de chromatographie intermédiaire.