WO2025158381 - METHODS FOR ENHANCING ADENO-ASSOCIATED VIRUS (AAV) PRODUCTION
National phase entry is expected:
Publication Number
WO/2025/158381
Publication Date
31.07.2025
International Application No.
PCT/IB2025/050818
International Filing Date
24.01.2025
Title **
[English]
METHODS FOR ENHANCING ADENO-ASSOCIATED VIRUS (AAV) PRODUCTION
[French]
PROCÉDÉS D'AMÉLIORATION DE LA PRODUCTION DE VIRUS ADÉNO-ASSOCIÉ (AAV)
Applicants **
SANOFI
46 Avenue de la Grande Armée
75017 Paris, FR
Inventors
LI, Qingliang
c/o Sanofi, Patent Department
450 Water Street
Cambridge, Massachusetts 02141, US
NIE, Yingchao
c/o Sanofi, Patent Department
450 Water Street
Cambridge, Massachusetts 02141, US
PAN, Hao
c/o Sanofi, Patent Department
450 Water Street
Cambridge, Massachusetts 02141, US
Priority Data
24305146.3
26.01.2024
EP
63/644,013
08.05.2024
US
63/713,654
30.10.2024
US
Application details
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International Searching Authority |
EPO
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| Applicant's Legal Status |
Legal Entity
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| Entry into National Phase under |
Chapter I
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| Translation |
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Recalculate
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Quotation for National Phase entry
| Country | Stages | Total | |
|---|---|---|---|
| China | Filing | 3321 | |
| EPO | Filing, Examination | 31674 | |
| Japan | Filing | 595 | |
| South Korea | Filing | 640 | |
| USA | Filing, Examination | 14560 |
Total: 50790 USD
Abstract[English]
Compositions, systems, and methods for enhancing adenovirus L4 region 33K protein (Ad L4-33K) expression in an AAV producing cell are disclosed. For example, a system for AAV production including (a) a first nucleic acid molecule encoding an adenovirus L4-33K protein; and (b) a second nucleic acid molecule comprising adenovirus genes E2A, L4, E4, and VA RNA is described.[French]
L'invention concerne des compositions, des systèmes et des procédés pour améliorer l'expression de la protéine 33K de région L4 d'adénovirus (Ad L4-33K) dans une cellule de production d'AAV. Par exemple, l'invention concerne un système de production d'AAV comprenant (a) une première molécule d'acide nucléique codant pour une protéine L4-33 K d'adénovirus ; et (b) une seconde molécule d'acide nucléique comprenant des gènes d'adénovirus E2A, L4, E4 et un ARN VA.