WO2025099636 - ALBUMIN CONJUGATES AND RADIOPHARMACEUTICAL COMPOSITIONS THEREOF
National phase entry is expected:
Publication Number
WO/2025/099636
Publication Date
15.05.2025
International Application No.
PCT/IB2024/061049
International Filing Date
07.11.2024
Title **
[English]
ALBUMIN CONJUGATES AND RADIOPHARMACEUTICAL COMPOSITIONS THEREOF
[French]
CONJUGUÉS D'ALBUMINE ET COMPOSITIONS RADIOPHARMACEUTIQUES ASSOCIÉES
Applicants **
JUBILANT DRAXIMAGE INC
16751 TransCanada Highway, Kirkland
Montreal, Québec H9H 4J4, CA
Inventors
NANDI, Indranil
790 Township Line Road, Suite 175
Yardley, Pennsylvania 19067, US
KULANGARA, Vijayaraj Kuniyil
16751 TransCanada Highway, Kirkland
Montreal, Québec H9H 4J4, CA
SARWAL, Dinesh Kumar
Plot no. 15, Knowledge Park II, Greater Noida
Utter Pradesh 201306, IN
BHATTACHARYYA, Arundhati
Plot no. 15, Knowledge Park II, Greater Noida
Utter Pradesh 201306, IN
PENA, Miriam Ruiz
16751 TransCanada Highway, Kirkland
Montreal, Québec H9H 4J4, CA
ABREU DIAZ, Aida Mary
16751 TransCanada Highway, Kirkland
Montreal, Québec H9H 4J4, CA
Priority Data
63/597,218
08.11.2023
US
Application details
| Total Number of Claims/PCT | * |
| Number of Independent Claims | * |
| Number of Priorities | * |
| Number of Multi-Dependent Claims | * |
| Number of Drawings | * |
| Pages for Publication | * |
| Number of Pages with Drawings | * |
| Pages of Specification | * |
| * | |
| * | |
International Searching Authority |
CIPO
* |
| Applicant's Legal Status |
Legal Entity
* |
| * | |
| * | |
| * | |
| * | |
| Entry into National Phase under |
Chapter I
* |
| Translation |
|
* The data is based on automatic recognition. Please verify and amend if necessary.
** IP-Coster compiles data from publicly available sources. If this data includes your personal information, you can contact us to request its removal.
Quotation for National Phase entry
| Country | Stages | Total | |
|---|---|---|---|
| China | Filing | 1478 | |
| EPO | Filing, Examination | 9808 | |
| Japan | Filing | 591 | |
| South Korea | Filing | 574 | |
| USA | Filing, Examination | 4310 |
Total: 16,761 USD
Abstract[English]
The embodiments of the present invention disclose a conjugate compound of formula X-J- MAA, wherein X is a diagnostic or therapeutic radioisotope; J is an optional chelating agent; and MAA is macroaggregated albumin particles. The invention also discloses sterile and stable ready to use or reconstituted radiopharmaceutical composition of X-J-MAA and manufacturing process thereof. The prepared radiopharmaceutical compositions exhibit desirable technical attributes like stability, radiochemical purity, less impurities, pH, better bio-distribution and desirable average particle size for further administration to patients for therapeutic and diagnostic use[French]
Les modes de réalisation de la présente invention concernent un composé conjugué représenté par la formule X-J-MAA, dans laquelle X est un radio-isotope diagnostique ou thérapeutique ; J est un agent chélatant facultatif ; et MAA désigne des particules d'albumine macroagrégées. L'invention concerne également une composition radiopharmaceutique stérile et stable, prête à l'emploi ou reconstituée, de X-J-MAA et son procédé de fabrication. Les compositions radiopharmaceutiques préparées présentent des attributs techniques souhaitables tels qu'en termes de stabilité, pureté radiochimique, teneur inférieure en impuretés, pH, meilleure biodistribution et taille de particules moyenne souhaitable à des fins d'administration ultérieure à des patients pour usages thérapeutique et diagnostique.