WO2025088586 - COMPOSITIONS, SYSTEMS, AND METHODS FOR TREATING CANCER USING TUMOR TREATING FIELDS WITH INHIBITORS OF MIF, MICA, AND/OR MICB
National phase entry:
Publication Number
WO/2025/088586
Publication Date
01.05.2025
International Application No.
PCT/IB2024/060549
International Filing Date
25.10.2024
Title **
[English]
COMPOSITIONS, SYSTEMS, AND METHODS FOR TREATING CANCER USING TUMOR TREATING FIELDS WITH INHIBITORS OF MIF, MICA, AND/OR MICB
[French]
COMPOSITIONS, SYSTÈMES ET MÉTHODES DE TRAITEMENT DU CANCER À L'AIDE DE CHAMPS DE TRAITEMENT DE TUMEUR AVEC DES INHIBITEURS DE MIF, MICA ET/OU MICB
Applicants **
BROWN UNIVERSITY
NOVOCURE GMBH
Inventors
EL-DEIRY, Wafik
SRINIVASAN, Praveen
VOLOSHIN-SELA, Tali
Priority Data
63/593,790
27.10.2023
US
63/601,599
21.11.2023
US
Application details
| Total Number of Claims/PCT | * |
| Number of Independent Claims | * |
| Number of Priorities | * |
| Number of Multi-Dependent Claims | * |
| Number of Drawings | * |
| Pages for Publication | * |
| Number of Pages with Drawings | * |
| Pages of Specification | * |
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| Number of Office Actions | * |
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International Searching Authority |
EPO
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| Recordal of a Change of the Applicant's Name/Address |
Change of Applicant's Name and Address
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| Type of Assignment |
The Standard Agent's Assignment
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| Applicant's Legal Status |
Legal Entity
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| * | |
| * | |
| * | |
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| Entry into National Phase under |
Chapter I
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| Patent Delivery |
Send the Letters Patent by Courier
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| Translation |
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* The data is based on automatic recognition. Please verify and amend if necessary.
** IP-Coster compiles data from publicly available sources. If this data includes your personal information, you can contact us to request its removal.
Quotation for National Phase entry
| Country | Stages | Total | |
|---|---|---|---|
| China | Filing, Examination, Granting | 3834 | |
| EPO | Filing, Examination, Granting | 37104 | |
| Japan | Filing, Examination, Granting | 3514 | |
| South Korea | Filing, Examination, Granting | 5099 | |
| USA | Filing, Examination, Granting | 14190 |
Total:
63,741
The term for entry into the National Phase has expired. This quotation is for informational purposes only
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Abstract[English]
Compositions, systems, and advanced methods for reducing viability of cancer cells and treating cancer, as well as preventing an increase of volume of a tumor present in a body of a living subject, are disclosed. The systems and methods involve application of an alternating field concurrently with administration of at least one composition that inhibits at least one of immunomodulatory cytokine such as (but not limited to) macrophage migration inhibitory factor (MIF), MHC class I chain‐related polypeptide A (MICA), and/or MHC class I chain‐related polypeptide B (MICB).[French]
Des compositions, des systèmes ainsi que des méthodes avancées permettant de réduire la viabilité de cellules cancéreuses et de traiter le cancer, et de prévenir une augmentation du volume d'une tumeur présente dans le corps d'un sujet vivant, sont divulgués. Les systèmes et les méthodes consistent à appliquer un champ alternatif simultanément à l'administration d'au moins une composition qui inhibe au moins un élément parmi une cytokine immunomodulatrice telle que (mais sans s'y limiter) le facteur inhibiteur de la migration des macrophages (MIF), le polypeptide A lié à une chaîne du CMH de classe I (MICA) et/ou le polypeptide B lié à une chaîne du CMH de classe I (MICB).