WO2025172745 - SYSTEMS, SYSTEM COMPONENTS AND METHODS FOR AUTOMATED MACROMOLECULE SYNTHESIS
National phase entry is expected:
Publication Number
WO/2025/172745
Publication Date
21.08.2025
International Application No.
PCT/IB2024/059485
International Filing Date
27.09.2024
Title **
[English]
SYSTEMS, SYSTEM COMPONENTS AND METHODS FOR AUTOMATED MACROMOLECULE SYNTHESIS
[French]
SYSTÈMES, COMPOSANTS DE SYSTÈME ET PROCÉDÉS DE SYNTHÈSE AUTOMATISÉE DE MACROMOLÉCULE
Applicants **
ROCHE SEQUENCING SOLUTIONS, INC.
F. HOFFMANN-LA ROCHE AG
Inventors
PACABA, Donald
MILLER, Scott
CARROLL, Ali
LEPROWSE, Megan
BERG, Kendall
KELLER BARRETT, Salka
LEHMANN, Taylor
MCRUER, Robert
THIESSEN, Gregory Scott
ROSEVEAR, Chad
ROGERS-PECKHAM, Megan
PHAM, Kevin
BALASUBRAMANIAN, Meera
LEADBETTER, Joanne
AGHABABAZADEH, Majid
KOKORIS, Mark Stamatios
Priority Data
63/554,066
15.02.2024
US
Application details
| Total Number of Claims/PCT | * |
| Number of Independent Claims | * |
| Number of Priorities | * |
| Number of Multi-Dependent Claims | * |
| Number of Drawings | * |
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| Pages of Specification | * |
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| Number of Office Actions | * |
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International Searching Authority |
EPO
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| Recordal of a Change of the Applicant's Name/Address |
Change of Applicant's Name and Address
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| Type of Assignment |
The Standard Agent's Assignment
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| Applicant's Legal Status |
Legal Entity
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| * | |
| * | |
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| Entry into National Phase under |
Chapter I
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| Patent Delivery |
Send the Letters Patent by Courier
* |
| Translation |
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* The data is based on automatic recognition. Please verify and amend if necessary.
** IP-Coster compiles data from publicly available sources. If this data includes your personal information, you can contact us to request its removal.
Quotation for National Phase entry
| Country | Stages | Total | |
|---|---|---|---|
| China | Filing, Examination, Granting | 2312 | |
| EPO | Filing, Examination, Granting | 9234 | |
| Japan | Filing, Examination, Granting | 2181 | |
| South Korea | Filing, Examination, Granting | 2020 | |
| USA | Filing, Examination, Granting | 5340 |
Total:
21,087
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Abstract[English]
A system and method for automated synthesis of a macromolecule from a nucleic acid template is provided, which includes a flow cell with a sipper, a mount with a thermal block, a pump, a selectable valve, a holder, an XYZ gantry, and a controller. The flow cell can be held in a fixed position while the gantry can move the holder to sippers of the flow cell. In this configuration, the sipper length can be reduced or minimized to reduce loss of precious reagents and the synthesized macromolecule.[French]
L'invention concerne un système et un procédé de synthèse automatisée d'une macromolécule à partir d'un modèle d'acide nucléique, qui comprend une cuve à circulation avec un tube, un support avec un bloc thermique, une pompe, une soupape sélectionnable, un support, un portique XYZ et un dispositif de commande. La cuve à circulation peut être maintenue dans une position fixe tandis que le portique peut déplacer le support vers des supports de la cuve à circulation. Dans cette configuration, la longueur de tube peut être réduite ou réduite à un minimum pour réduire la perte de réactifs précieux et de la macromolécule synthétisée.