WO2025062362 - IL-5R-ALPHA ANTIBODIES FOR TREATING EOSINOPHILIC GRANULOMATOSIS WITH POLYANGIITIS

National phase entry:
Publication Number WO/2025/062362
Publication Date 27.03.2025
International Application No. PCT/IB2024/059168
International Filing Date 20.09.2024
Title **
[English] IL-5R-ALPHA ANTIBODIES FOR TREATING EOSINOPHILIC GRANULOMATOSIS WITH POLYANGIITIS
[French] ANTICORPS IL-5R-ALPHA POUR LE TRAITEMENT DE LA GRANULOMATOSE ÉOSINOPHILE AVEC POLYANGÉITE
Applicants **
ASTRAZENECA AB
Inventors
DUNCAN, Elizabeth
NECANDER, Sofia
D'ANGELO, Gina
BÖRJESSON SJÖ, Lena
Priority Data
63/584,453   21.09.2023   US
63/597,634   09.11.2023   US
63/648,325   16.05.2024   US
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Quotation for National Phase entry

Country StagesTotal
China Filing, Examination, Granting4206
EPO Filing, Examination, Granting48597
Japan Filing, Examination, Granting3727
South Korea Filing, Examination, Granting5325
USA Filing, Examination, Granting14390
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Total: 76,245

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Abstract[English] Provided herein are methods of treating Eosinophilic Granulomatosis with Polyangiitis (EGPA) comprising administering to the subject a therapeutically effective amount of an anti- interleukin-5 receptor alpha (IL-5Rα) antibody or an antigen-binding fragment thereof such as benralizumab.[French] L'invention concerne des méthodes de traitement de la granulomatose éosinophile avec polyangéite (GEPA) comprenant l'administration au sujet d'une quantité thérapeutiquement efficace d'un anticorps anti-récepteur alpha de l'interleukine-5 (IL-5Rα) ou d'un fragment de liaison à l'antigène de celui-ci tel que le benralizumab.