WO2025041034 - PROMOTER FOR THE SPECIFIC EXPRESSION OF GENES IN LAYER 5 CELLS IN MOUSE CORTEX

National phase entry is expected:
Publication Number WO/2025/041034
Publication Date 27.02.2025
International Application No. PCT/IB2024/058072
International Filing Date 20.08.2024
Title **
[English] PROMOTER FOR THE SPECIFIC EXPRESSION OF GENES IN LAYER 5 CELLS IN MOUSE CORTEX
[French] PROMOTEUR POUR L'EXPRESSION SPÉCIFIQUE DE GÈNES DANS DES CELLULES DE COUCHE 5 DANS UN CORTEX DE SOURIS
Applicants **
FRIEDRICH MIESCHER INSTITUTE FOR BIOMEDICAL RESEARCH
Inventors
KELLER, Georg
SAENZ DE BURUAGA CORROCHANO, Beatriz Lucia
Priority Data
23192647.8   22.08.2023   EP
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Quotation for National Phase entry

Country StagesTotal
China Filing, Examination, Granting1938
EPO Filing, Examination, Granting8126
Japan Filing, Examination, Granting2062
South Korea Filing, Examination, Granting1883
USA Filing, Examination, Granting7140
MasterCard Visa
Total: 21,149

The term for entry into the National Phase has expired. This quotation is for informational purposes only

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Abstract[English] The present invention provides an isolated nucleic acid molecule comprising, or consisting of, the nucleic acid sequence of SEQ ID NO:1 or of a nucleic acid sequence of at least 1400 bp having at least 80% identity to said sequence of SEQ ID NO:1, wherein said isolated nucleic acid molecule leads to the specific expression of an exogenous gene in layer 5 cells in mouse cortex when a nucleic acid sequence coding for said exogenous gene is operatively linked to said isolated nucleic acid molecule.[French] La présente invention concerne une molécule d'acide nucléique isolée comprenant, ou consistant en, la séquence d'acide nucléique de SEQ ID NO : 1 ou d'une séquence d'acide nucléique d'au moins 1400 pb ayant au moins 80% d'identité avec ladite séquence de SEQ ID NO : 1, ladite molécule d'acide nucléique isolée conduisant à l'expression spécifique d'un gène exogène dans les cellules de couche 5 dans le cortex de souris lorsqu'une séquence d'acide nucléique codant pour ledit gène exogène est liée de manière fonctionnelle à ladite molécule d'acide nucléique isolée.