WO2025003978 - DEVICE AND METHODS FOR ADMINISTERING A THERAPEUTIC COMPOSITION TO THE PHARYNGEAL MUSCLE

National phase entry:
Publication Number WO/2025/003978
Publication Date 02.01.2025
International Application No. PCT/IB2024/056310
International Filing Date 28.06.2024
Title **
[English] DEVICE AND METHODS FOR ADMINISTERING A THERAPEUTIC COMPOSITION TO THE PHARYNGEAL MUSCLE
[French] DISPOSITIF ET PROCÉDÉS D'ADMINISTRATION D'UNE COMPOSITION THÉRAPEUTIQUE AU MUSCLE PHARYNGÉ
Applicants **
BENITEC IP HOLDINGS INC. Corporation Trust Centre, 1209 Orange Street City of Wilmington, Delaware 19801, US
Inventors
MUKADAM, Sophie c/o Benitec Biopharma Inc. 3940 Trust Way Hayward, California 94545, US
BANKS, Jerel c/o Benitec Biopharma Inc. 3940 Trust Way Hayward, California 94545, US
ST-GUILY, Jean Lacau c/o Benitec Biopharma Inc. 3940 Trust Way Hayward, California 94545, US
Priority Data
63/510,750   28.06.2023   US
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Quotation for National Phase entry

Country StagesTotal
China Filing3049
EPO Filing, Examination33454
Japan Filing588
South Korea Filing574
USA Filing, Examination15310
MasterCard Visa

Total: 52975

The term for entry into the National Phase has expired. This quotation is for informational purposes only

Abstract[English] The present disclosure relates to devices and methods for administration of a therapeutic composition to the pharyngeal muscle. In particular, the devices and methods of the disclosure may be used in treatment or prevention of dysphagia, including dysphagia associated with oculopharyngeal muscular dystrophy (OPMD) in individuals suffering therefrom or predisposed thereto. Additionally, the present disclosure relates to devices and methods used to deliver modified adeno-associated virus (AAV) delivery vectors comprising 'silence and replace' DNA constructs, including compositions comprising same.[French] La présente divulgation concerne des dispositifs et des procédés d'administration d'une composition thérapeutique au muscle pharyngé. En particulier, les dispositifs et les procédés de la divulgation peuvent être utilisés dans le traitement ou la prévention de la dysphagie, notamment la dysphagie associée à la dystrophie musculaire oculopharyngée (OPMD), chez des individus atteints de celle-ci ou prédisposés à celle-ci. De plus, la présente divulgation concerne des dispositifs et des procédés utilisés pour administrer des vecteurs d'administration de virus adéno-associé (AAV) modifiés comprenant des constructions d'ADN « silence et remplacement », notamment des compositions les comprenant.
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