WO2024257052 - CYCLIC BUILDUP OF BIOFILMS IN SMALL TO MEDIUM-SIZED LUMENS
National phase entry is expected:
Publication Number
WO/2024/257052
Publication Date
19.12.2024
International Application No.
PCT/IB2024/055864
International Filing Date
14.06.2024
Title **
[English]
CYCLIC BUILDUP OF BIOFILMS IN SMALL TO MEDIUM-SIZED LUMENS
[French]
ACCUMULATION CYCLIQUE DE BIOFILMS DANS DES LUMIÈRES DE PETITE À MOYENNE TAILLE
Applicants **
SABAN VENTURES PTY LIMITED
Building A, Level 1, 11 Talavera Rd
Macquarie Park, New South Wales 2113, AU
Inventors
BURDACH, Jonathan Graeme
Building A, Level 1, 11 Talavera Rd
Macquarie Park, New South Wales 2113, AU
NAJNIN, Tahria
Building A, Level 1, 11 Talavera Rd
Macquarie Park, New South Wales 2113, AU
STANCZAK, Aleksandra Maria
Building A, Level 1, 11 Talavera Rd
Macquarie Park, New South Wales 2113, AU
PATHROSE, Blessy
Building A, Level 1, 11 Talavera Rd
Macquarie Park, New South Wales 2113, AU
KAUR, Kiranjit
Building A, Level 1, 11 Talavera Rd
Macquarie Park, New South Wales 2113, AU
SHAH, Vaibhav Bipinchandra
Building A, Level 1, 11 Talavera Rd
Macquarie Park, New South Wales 2113, AU
Priority Data
63/508,029
14.06.2023
US
Application details
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International Searching Authority |
IP Australia
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| Applicant's Legal Status |
Legal Entity
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| Entry into National Phase under |
Chapter I
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| Translation |
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Quotation for National Phase entry
| Country | Stages | Total | |
|---|---|---|---|
| China | Filing | 1925 | |
| EPO | Filing, Examination | 15975 | |
| Japan | Filing | 533 | |
| South Korea | Filing | 575 | |
| USA | Filing, Examination | 7235 |
Total: 26243 USD
Abstract[English]
Provided are multi-cyclic methods for simulating the deposition of stable biofilms on the inner walls of small to medium inner diameter lumens found in medical devices such as endoscopes. Multiple embodiments, including four- and two-cycle versions of the cyclic build- up biofilm (CBB) model were developed for depositing tough and stable bacterial biofilms in the lumens having relatively small or medium sized internal diameters (≤ 2.5 mm ID). The resulting stable biofilms resemble the difficult to remove biofilms found in small lumened medical devices and provide a reliable model for simulating build-up that takes place over time in clinical settings. The CBB model also may be applicable to larger-lumened medical devices. Also provided are methods of cleaning such biofilms from lumens.[French]
La présente invention concerne des procédés multicycliques permettant de simuler le dépôt de biofilms stables sur les parois internes des lumières de diamètre interne petit à moyen que l'on trouve dans les dispositifs médicaux tels que les endoscopes. De multiples modes de réalisation, comprenant des versions à quatre et deux cycles du modèle de biofilm d'accumulation cyclique (CBB) ont été développés pour déposer des biofilms bactériens résistants et stables dans les lumières de diamètres internes de taille relativement petite ou moyenne (≤ 2,5 mm ID). Les biofilms stables qui en résultent ressemblent aux biofilms difficiles à éliminer que l'on trouve dans les petits dispositifs médicaux à lumière et constituent un modèle fiable pour simuler l'accumulation qui se produit au fil du temps dans les milieux cliniques. Le modèle CBB peut également être applicable à des dispositifs médicaux plus grands. L'invention concerne également des procédés de nettoyage de tels biofilms à partir de lumières.