WO2024257037 - FRAGMENT TYPE DRIVEN SPECTRAL PEAK

National phase entry:
Publication Number WO/2024/257037
Publication Date 19.12.2024
International Application No. PCT/IB2024/055837
International Filing Date 14.06.2024
Title **
[English] FRAGMENT TYPE DRIVEN SPECTRAL PEAK
[French] PIC SPECTRAL COMMANDÉ DE TYPE FRAGMENT
Applicants **
DH TECHNOLOGIES DEVELOPMENT PTE. LTD. 33 Marsiling Industrial Estate Road 3 #04-06 Singapore 739256, SG
Inventors
DUCHOSLAV, Eva c/o Sciex 71 Four Valley Drive Concord, Ontario L4K 4V8, CA
Priority Data
63/508,185   14.06.2023   US
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Quotation for National Phase entry

Country StagesTotal
China Filing1168
EPO Filing, Examination4727
Japan Filing590
South Korea Filing575
USA Filing, Examination2710
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Total: 9770

The term for entry into the National Phase has expired. This quotation is for informational purposes only

Abstract[English] A method for annotating product ions of a spectrum is disclosed. A product ion mass spectrum is received. A parameter that indicates the mass spectrum was produced using a radical-induced dissociation method is received. At least one charge state mass-to-charge ratio (m/z) adjustment based on the parameter is performed for at least one product ion peak of the mass spectrum and the adjustment is compared to one or more other product ion peaks of the mass spectrum. The at least one product ion peak is annotated based on the comparison. The charge state adjustment includes the loss of an electron or the loss or gain of a hydrogen atom. The radical-induced dissociation method includes electron-based dissociation (ExD), ultraviolet photodissociation (UVPD), or infrared photodissociation (IRMPD).[French] L'invention concerne un procédé d'annotation d'ions produits d'un spectre. Un spectre de masse d'ions produits est reçu. Un paramètre indiquant que le spectre de masse a été produit à l'aide d'un procédé de dissociation induite par radicaux est reçu. Au moins un ajustement du rapport masse/charge (m/z) de l'état de charge basé sur le paramètre est effectué pour au moins un pic d'ion produit du spectre de masse et l'ajustement est comparé à un ou plusieurs autres pics d'ion produit du spectre de masse. Le ou les pics d'ions produits sont annotés sur la base de la comparaison. L'ajustement d'état de charge comprend la perte d'un électron ou la perte ou le gain d'un atome d'hydrogène. Le procédé de dissociation induite par radicaux comprend une dissociation à base d'électrons (ExD), une photodissociation par ultraviolets (UVPD) ou une photodissociation infrarouge (IRMPD).
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