WO2024246657 - METHOD FOR CONJUGATION AND PURIFICATION OF ANTIBODY DRUG CONJUGATE
National phase entry is expected:
Publication Number
WO/2024/246657
Publication Date
05.12.2024
International Application No.
PCT/IB2024/054797
International Filing Date
17.05.2024
Title **
[English]
METHOD FOR CONJUGATION AND PURIFICATION OF ANTIBODY DRUG CONJUGATE
[French]
PROCÉDÉ DE CONJUGAISON ET DE PURIFICATION D'UN CONJUGUÉ ANTICORPS-MÉDICAMENT
Applicants **
INTAS PHARMACEUTICALS LTD.
Inventors
JOGLEKAR, Tushar
KUMAWAT, Rakesh
JOSHI, Kopal
HARER, Amol
MONDAL, Sumantra
DESHPANDE, Pratik
ADHIKARY, Laxmi
Priority Data
202321036862
29.05.2023
IN
Application details
| Total Number of Claims/PCT | * |
| Number of Independent Claims | * |
| Number of Priorities | * |
| Number of Multi-Dependent Claims | * |
| Number of Drawings | * |
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| Number of Pages with Drawings | * |
| Pages of Specification | * |
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| Number of Office Actions | * |
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International Searching Authority |
IP India
* |
| Recordal of a Change of the Applicant's Name/Address |
Change of Applicant's Name and Address
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| Type of Assignment |
The Standard Agent's Assignment
* |
| Applicant's Legal Status |
Legal Entity
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| * | |
| * | |
| * | |
| * | |
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| Entry into National Phase under |
Chapter I
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| Patent Delivery |
Send the Letters Patent by Courier
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| Translation |
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* The data is based on automatic recognition. Please verify and amend if necessary.
** IP-Coster compiles data from publicly available sources. If this data includes your personal information, you can contact us to request its removal.
Quotation for National Phase entry
| Country | Stages | Total | |
|---|---|---|---|
| China | Filing, Examination, Granting | 1951 | |
| EPO | Filing, Examination, Granting | 11536 | |
| Japan | Filing, Examination, Granting | 1899 | |
| South Korea | Filing, Examination, Granting | 1508 | |
| USA | Filing, Examination, Granting | 4740 |
Total:
21,634
The term for entry into the National Phase has expired. This quotation is for informational purposes only
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Abstract[English]
The present invention relates to the method for conjugation and purification of antibody drug conjugate wherein, the method controls drug to antibody ratio (DAR) and species distribution of antibody drug conjugate, such as Trastuzumab emtansine. The method of the present invention involves conjugation reaction controlled using static mixer and hydrophobic interaction chromatography (HIC) operated in flow through mode.[French]
La présente invention concerne le procédé de conjugaison et de purification d'un conjugué anticorps-médicament, le procédé régulant le rapport médicament sur anticorps (DAR) et la distribution d'espèces du conjugué anticorps-médicament, tel que le trastuzumab emtansine. Le procédé de la présente invention implique une réaction de conjugaison contrôlée à l'aide d'un mélangeur statique et d'une chromatographie d'interaction hydrophobe (HIC) actionnée en mode d'écoulement.