WO2024231883 - RE-EDITABLE TEMPLATES, CELLS, COMPOSITIONS AND METHODS OF MAKING
National phase entry is expected:
Publication Number
WO/2024/231883
Publication Date
14.11.2024
International Application No.
PCT/IB2024/054536
International Filing Date
09.05.2024
Title **
[English]
RE-EDITABLE TEMPLATES, CELLS, COMPOSITIONS AND METHODS OF MAKING
[French]
MATRICES REMODIFIABLES, CELLULES, COMPOSITIONS ET PROCÉDÉS DE PRODUCTION
Applicants **
TAKEDA PHARMACEUTICAL COMPANY LIMITED
1-1, Doshomachi 4-chome
Chuo-ku
Osaka-shi, Osaka 541-0045, JP
STEELE, John
c/o Takeda Pharmaceutical Company Limited
9625 Towne Centre Drive
San Diego, California 92121, US
BORLADO, Luis
c/o Takeda Pharmaceutical Company Limited
9625 Towne Centre Drive
San Diego, California 92121, US
Inventors
STEELE, John
c/o Takeda Pharmaceutical Company Limited
9625 Towne Centre Drive
San Diego, California 92121, US
BORLADO, Luis
c/o Takeda Pharmaceutical Company Limited
9625 Towne Centre Drive
San Diego, California 92121, US
Priority Data
63/465,352
10.05.2023
US
Application details
| Total Number of Claims/PCT | * |
| Number of Independent Claims | * |
| Number of Priorities | * |
| Number of Multi-Dependent Claims | * |
| Number of Drawings | * |
| Pages for Publication | * |
| Number of Pages with Drawings | * |
| Pages of Specification | * |
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International Searching Authority |
EPO
* |
| Applicant's Legal Status |
Legal Entity
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| * | |
| * | |
| * | |
| * | |
| Entry into National Phase under |
Chapter I
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| Translation |
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Recalculate
* The data is based on automatic recognition. Please verify and amend if necessary.
** IP-Coster compiles data from publicly available sources. If this data includes your personal information, you can contact us to request its removal.
Quotation for National Phase entry
| Country | Stages | Total | |
|---|---|---|---|
| China | Filing | 3440 | |
| EPO | Filing, Examination | 50746 | |
| Japan | Filing | 532 | |
| South Korea | Filing | 575 | |
| USA | Filing, Examination | 18635 |
Total: 73928 USD
Abstract[English]
The present invention provides, among other things, methods of engineering a re- editable target locus in a cell, comprising inserting an exogenous re-editable template sequence to a target locus and methods of engineering a re-editable cell comprising a re- editable template sequence flanked by two homology arms such that the re-editable template sequence is inserted into a target locus by homologous recombination, and methods of using the same. In some aspects, provided is a re-editable template sequence, wherein the template sequence has no substantial sequence similarity to any region in the genome, and wherein the template sequence is recognizable by a genome editing system.[French]
La présente invention concerne, entre autres, des procédés d'ingénierie d'un locus cible remodifiable dans une cellule, comprenant l'insertion d'une séquence modèle exogène remodifiable dans un locus cible et des procédés d'ingénierie d'une cellule remodifiable comprenant une séquence matrice remodifiable flanquée de deux bras d'homologie de sorte que la séquence matrice remodifiable est insérée dans un locus cible par recombinaison homologue, ainsi que des procédés d'utilisation associés. Selon certains aspects, la présente invention concerne une séquence matrice remodifiable, la séquence matrice ne présentant pratiquement aucune similitude de séquence avec une région du génome, et la séquence matrice étant reconnaissable par un système d'édition génomique.