WO2025215403 - PREPARATION OF CRYSTALLINE FORM 2 INUPADENANT HYDROCHLORIDE
National phase entry is expected:
Publication Number
WO/2025/215403
Publication Date
16.10.2025
International Application No.
PCT/IB2024/053563
International Filing Date
11.04.2024
Title **
[English]
PREPARATION OF CRYSTALLINE FORM 2 INUPADENANT HYDROCHLORIDE
[French]
PRÉPARATION DE CHLORHYDRATE D'INUPADENANT CRISTALLIN DE FORME 2
Applicants **
ITEOS BELGIUM SA
Rue des Frères Wright 29
B-6041 Gosselies, BE
Inventors
SCHILS, Didier
c/o iTeos Belgium SA
Rue des Frères Wright 29
B-6041 Gosselies, BE
TUMMALA, Arjun
c/o iTeos Belgium SA
Rue des Frères Wright 29
B-6041 Gosselies, BE
BOOTH, David
c/o iTeos Belgium SA
Rue des Frères Wright 29
B-6041 Gosselies, BE
Application details
| Total Number of Claims/PCT | * |
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International Searching Authority |
EPO
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| Applicant's Legal Status |
Legal Entity
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| Entry into National Phase under |
Chapter I
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| Translation |
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Quotation for National Phase entry
| Country | Stages | Total | |
|---|---|---|---|
| China | Filing | 1387 | |
| EPO | Filing, Examination | 8459 | |
| Japan | Filing | 595 | |
| South Korea | Filing | 482 | |
| USA | Filing, Examination | 4510 |
Total: 15433 USD
Abstract[English]
The present disclosure relates to an improved process of preparing crystalline Form 2 inupadenant hydrochloride. In some embodiments, the process of preparing crystalline Form 2 inupadenant hydrochloride does not result in the preparation of crystalline Form 1 inupadenant hydrochloride. In some embodiments, the process of preparing crystalline Form 2 inupadenant hydrochloride results in inupadenant hydrochloride that is substantially crystalline Form 2 inupadenant hydrochloride. In some embodiments, the process of preparing crystalline Form 2 inupadenant hydrochloride comprises combining inupadenant in a suitable solvent system with hydrochloric acid, wherein the hydrochloric acid may be delivered in solution or by gas.[French]
La présente divulgation concerne un procédé amélioré pour la préparation de chlorhydrate d'inupadenant cristallin de forme 2. Dans certains modes de réalisation, le procédé de préparation de chlorhydrate d'inupadenant cristallin de forme 2 ne conduit pas à la préparation de chlorhydrate d'inupadenant cristallin de forme 1. Dans certains modes de réalisation, le procédé de préparation de chlorhydrate d'inupadenant cristallin de forme 2 conduit à un chlorhydrate d'inupadenant qui est sensiblement du chlorhydrate d'inupadenant de forme 2 sensiblement cristallin. Dans certains modes de réalisation, le procédé de préparation de chlorhydrate d'inupadenant cristallin de forme 2 comprend la combinaison d'inupadenant dans un système de solvant approprié avec de l'acide chlorhydrique, l'acide chlorhydrique pouvant être administré en solution ou par gaz.