WO2024201423 - MICROTUBULE-ASSOCIATED PROTEIN TAU TARGETING SIRNAS AND USES THEREOF
National phase entry is expected:
Publication Number
WO/2024/201423
Publication Date
03.10.2024
International Application No.
PCT/IB2024/053120
International Filing Date
29.03.2024
Title **
[English]
MICROTUBULE-ASSOCIATED PROTEIN TAU TARGETING SIRNAS AND USES THEREOF
[French]
ARNSI CIBLANT LA PROTÉINE TAU ASSOCIÉE AUX MICROTUBULES ET LEURS UTILISATIONS
Applicants **
BIORCHESTRA CO., LTD.
2F-216, Venture-dong, KRIBB, 125, Gwahak-ro
Yuseong-gu
Daejeon 34141, KR
Inventors
RYU, Jin-Hyeob
c/o BIORCHESTRA CO., LTD.
2F-216, Venture-dong, KRIBB, 125, Gwahak-ro
Yuseong-gu
Daejeon 34141, KR
PARK, Young Jin
c/o BIORCHESTRA CO., LTD.
2F-216, Venture-dong, KRIBB, 125, Gwahak-ro
Yuseong-gu
Daejeon 34141, KR
PARK, Suhyeong
c/o BIORCHESTRA CO., LTD.
2F-216, Venture-dong, KRIBB, 125, Gwahak-ro
Yuseong-gu
Daejeon 34141, KR
LIM, Yu Na
c/o BIORCHESTRA CO., LTD.
2F-216, Venture-dong, KRIBB, 125, Gwahak-ro
Yuseong-gu
Daejeon 34141, KR
KIM, Insun
c/o BIORCHESTRA CO., LTD.
2F-216, Venture-dong, KRIBB, 125, Gwahak-ro
Yuseong-gu
Daejeon 34141, KR
KWON, Mincheol
c/o BIORCHESTRA CO., LTD.
2F-216, Venture-dong, KRIBB, 125, Gwahak-ro
Yuseong-gu
Daejeon 34141, KR
KIM, Jihye
c/o BIORCHESTRA CO., LTD.
2F-216, Venture-dong, KRIBB, 125, Gwahak-ro
Yuseong-gu
Daejeon 34141, KR
Priority Data
63/493,244
30.03.2023
US
Quotation for National Phase entry
Abstract[English]
The present disclosure relates to siRNA, which target MAPT transcript in a cell, leading to reduced expression of MAPT protein. Reduction of MAPT protein expression is beneficial for the treatment of certain medical disorders, e.g., a tauopathy.[French]
La présente invention concerne un ARNsi qui cible un transcrit MAPT dans une cellule, conduisant à une expression réduite de la protéine MAPT. La réduction de l'expression de la protéine MAPT est bénéfique pour le traitement de certains troubles médicaux, par exemple, une tauopathie.