WO2024194800 - SYSTEMS AND METHODS FOR PURITY CALCULATION FOR THE COMPOUND QC WORKFLOW
National phase entry is expected:
Publication Number
WO/2024/194800
Publication Date
26.09.2024
International Application No.
PCT/IB2024/052652
International Filing Date
19.03.2024
Title **
[English]
SYSTEMS AND METHODS FOR PURITY CALCULATION FOR THE COMPOUND QC WORKFLOW
[French]
SYSTÈMES ET PROCÉDÉS DE CALCUL DE PURETÉ POUR LE FLUX DE TRAVAIL DE CQ D'UN COMPOSÉ
Applicants **
DH TECHNOLOGIES DEVELOPMENT PTE. LTD.
33 Marsiling Industrial Estate Road 3
#04-06
Singapore 739256, SG
Inventors
IVOSEV, Gordana
c/o Sciex
71 Four Valley Drive
Concord, Ontario L4K 4V8, CA
LIU, Chang
c/o Sciex
71 Four Valley Drive
Concord, Ontario L4K 4V8, CA
Priority Data
63/491,513
21.03.2023
US
Application details
| Total Number of Claims/PCT | * |
| Number of Independent Claims | * |
| Number of Priorities | * |
| Number of Multi-Dependent Claims | * |
| Number of Drawings | * |
| Pages for Publication | * |
| Number of Pages with Drawings | * |
| Pages of Specification | * |
| * | |
| * | |
International Searching Authority |
EPO
* |
| Applicant's Legal Status |
Legal Entity
* |
| * | |
| * | |
| * | |
| * | |
| Entry into National Phase under |
Chapter I
* |
| Translation |
|
Recalculate
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Quotation for National Phase entry
| Country | Stages | Total | |
|---|---|---|---|
| China | Filing | 2310 | |
| EPO | Filing, Examination | 18410 | |
| Japan | Filing | 535 | |
| South Korea | Filing | 576 | |
| USA | Filing, Examination | 9035 |
Total: 30866 USD
The term for entry into the National Phase has expired. This quotation is for informational purposes only
Abstract[English]
A method for quantifying a purity of a target analyte in a sample includes introducing into a mass spectrometer, via a sample introduction, a plurality of sample ions generated by ionizing at least a portion of analytes in the sample; obtaining, via the mass spectrometer, a plurality of mass spectra including a sample mass spectrum associated with the sample introduction; analyzing the sample mass spectrum to identify a target signal corresponding to the target analyte; deriving, from the target signal, a target signal intensity corresponding to the target analyte; deriving, from at least a portion of the sample mass spectrum, a sample signal intensity; and quantifying the purity of the target analyte based on the target signal intensity and the sample signal intensity.[French]
Selon l'invention, un procédé de quantification d'une pureté d'un analyte cible dans un échantillon consiste à introduire dans un spectromètre de masse, par l'intermédiaire d'une introduction d'échantillon, une pluralité d'ions d'échantillon générés par ionisation d'au moins une partie d'analytes dans l'échantillon ; obtenir, par l'intermédiaire du spectromètre de masse, une pluralité de spectres de masse comprenant un spectre de masse d'échantillon associé à l'introduction d'échantillon ; analyser le spectre de masse d'échantillon pour identifier un signal cible correspondant à l'analyte cible ; dériver, à partir du signal cible, une intensité de signal cible correspondant à l'analyte cible ; dériver, à partir d'au moins une partie du spectre de masse d'échantillon, une intensité de signal d'échantillon ; et quantifier la pureté de l'analyte cible sur la base de l'intensité de signal cible et de l'intensité de signal d'échantillon.