WO2024189583 - PEPTIDE EXPRESSION CONSTRUCTS AND USES THEREOF
National phase entry is expected:
Publication Number
WO/2024/189583
Publication Date
19.09.2024
International Application No.
PCT/IB2024/052507
International Filing Date
14.03.2024
Title **
[English]
PEPTIDE EXPRESSION CONSTRUCTS AND USES THEREOF
[French]
CONSTRUCTIONS D'EXPRESSION DE PEPTIDES ET LEURS UTILISATIONS
Applicants **
GOJO, Satoshi
c/o KYOTO PREFECTURAL PUBLIC UNIVERSITY CORPORATION
465, Kajii-cho, Kawaramachi-dori Hirokoji-agaru, Kamigyo-ku
Kyoto, Kyoto 602-8566, JP
KYOTO PREFECTURAL PUBLIC UNIVERSITY CORPORATION
465, Kajii-cho, Kawaramachi-dori Hirokoji-agaru, Kamigyo-ku
Kyoto, Kyoto 602-8566, JP
Inventors
GOJO, Satoshi
c/o KYOTO PREFECTURAL PUBLIC UNIVERSITY CORPORATION
465, Kajii-cho, Kawaramachi-dori Hirokoji-agaru, Kamigyo-ku
Kyoto, Kyoto 602-8566, JP
Priority Data
63/490,324
15.03.2023
US
Application details
| Total Number of Claims/PCT | * |
| Number of Independent Claims | * |
| Number of Priorities | * |
| Number of Multi-Dependent Claims | * |
| Number of Drawings | * |
| Pages for Publication | * |
| Number of Pages with Drawings | * |
| Pages of Specification | * |
| * | |
| * | |
International Searching Authority |
EPO
* |
| Applicant's Legal Status |
Legal Entity
* |
| * | |
| * | |
| * | |
| * | |
| Entry into National Phase under |
Chapter I
* |
| Translation |
|
Recalculate
* The data is based on automatic recognition. Please verify and amend if necessary.
** IP-Coster compiles data from publicly available sources. If this data includes your personal information, you can contact us to request its removal.
Quotation for National Phase entry
| Country | Stages | Total | |
|---|---|---|---|
| China | Filing | 2316 | |
| EPO | Filing, Examination | 15214 | |
| Japan | Filing | 535 | |
| South Korea | Filing | 576 | |
| USA | Filing, Examination | 13085 |
Total: 31726 USD
The term for entry into the National Phase has expired. This quotation is for informational purposes only
Abstract[English]
The disclosure provides gene transfer constructs comprising a destabilizing domain (DD) sequence, a translational separator sequence, and a sequence encoding one or more copies of one or more peptides of interest; nucleic acids encoding gene transfer constructs; uses of nucleic acids encoding gene transfer constructs to prevent mitochondrial hyperfission and fragmentation; uses of nucleic acids encoding gene transfer constructs to induce apoptosis in cells, such as cancer cells; and therapeutic applications of nucleic acids encoding gene transfer constructs, for example, in the treatment of mitochondrial diseases and disorders associated with mitochondrial dysfunction, as well as various types of cancer.[French]
L'invention concerne : des constructions de transfert de gène comprenant une séquence de domaine de déstabilisation (DD), une séquence de séparateur de traduction, et une séquence codant pour une ou plusieurs copies d'un ou de plusieurs peptides d'intérêt ; des utilisations d'acides nucléiques codant pour des constructions de transfert de gène pour empêcher une hyperfission et une fragmentation mitochondriales ; des utilisations d'acides nucléiques codant pour des constructions de transfert de gène pour induire l'apoptose dans des cellules, telles que des cellules cancéreuses ; et des applications thérapeutiques d'acides nucléiques codant pour des constructions de transfert de gène, par exemple, dans le traitement de maladies et de troubles mitochondriaux associés à un dysfonctionnement mitochondrial, ainsi que divers types de cancer.