WO2024171082 - STABLE PROTEIN COMPOSITIONS OF ANTI-PD1 ANTIBODY

National phase entry:
Publication Number WO/2024/171082
Publication Date 22.08.2024
International Application No. PCT/IB2024/051388
International Filing Date 14.02.2024
Title **
[English] STABLE PROTEIN COMPOSITIONS OF ANTI-PD1 ANTIBODY
[French] COMPOSITIONS DE PROTÉINES STABLES D'ANTICORPS ANTI-PD1
Applicants **
SUN PHARMACEUTICAL INDUSTRIES LIMITED
Inventors
SHAH, Bhavik Kumar
SHARMA, Manish
JOGANI, Viralkumar Vinodlal
KHOPADE, Ajay Jaysingh
NAGARAJA, Ravishankara Madavati
CHOUHAN, Pankaj Singh
Priority Data
202321010367   16.02.2023   IN
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Quotation for National Phase entry

Country StagesTotal
China Filing, Examination, Granting2651
EPO Filing, Examination, Granting18290
Japan Filing, Examination, Granting2776
South Korea Filing, Examination, Granting3159
USA Filing, Examination, Granting15940
MasterCard Visa
Total: 42,816

The term for entry into the National Phase has expired. This quotation is for informational purposes only

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Abstract[English] The invention relates to stable compositions of an antibody against human programmed death receptor PD-1, or antigen binding fragments thereof. The invention further provides methods for treating various cancers with stable formulations of the invention. The present invention relates to pharmaceutical compositions of an anti-PD1 antibody comprising a buffer, a sugar or sugar alcohol and a surfactant. In some embodiments of the invention, the formulations may be administered to a subject by intravenous or subcutaneous administration.[French] L'invention concerne des compositions stables d'un anticorps dirigé contre le récepteur de mort programmée humaine PD-1, ou des fragments de liaison à l'antigène de celui-ci. L'invention concerne en outre des procédés de traitement de divers cancers avec des formulations stables de l'invention. La présente invention concerne des compositions pharmaceutiques d'un anticorps anti-PD1 comprenant un tampon, un sucre ou un alcool de sucre et un tensioactif. Dans certains modes de réalisation de l'invention, les formulations peuvent être administrées à un sujet par administration intraveineuse ou sous-cutanée.

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