WO2024166003 - NON-INVASIVE TUNING OF PROTEIN ALIGNMENT
National phase entry is expected:
Publication Number
WO/2024/166003
Publication Date
15.08.2024
International Application No.
PCT/IB2024/051112
International Filing Date
07.02.2024
Title **
[English]
NON-INVASIVE TUNING OF PROTEIN ALIGNMENT
[French]
ACCORD NON INVASIF D'ALIGNEMENT DE PROTÉINES
Applicants **
NEW YORK UNIVERSITY IN ABU DHABI CORPORATION
Saddiyat Island, PO Box 129188
Abu Dhabi, AE
Inventors
TEO, Jeremy C.M.
Al Zeina Apt. C1 882, Al Raha Beach
Abu Dhabi, AE
SAPUDOM, Jiranuwat
Al Jowhara Tower, Apt. 2909
Abu Dhabi, AE
GARCIA-SABATÉ, Anna
46 Meyer Rd, #07-01
Singapore, SG
QUARTEY, Brian Chesney
NYU Abu Dhabi, Saadiyat Island, P.O. Box 129188
Abu Dhabi, AE
Priority Data
63/483,676
07.02.2023
US
Application details
| Total Number of Claims/PCT | * |
| Number of Independent Claims | * |
| Number of Priorities | * |
| Number of Multi-Dependent Claims | * |
| Number of Drawings | * |
| Pages for Publication | * |
| Number of Pages with Drawings | * |
| Pages of Specification | * |
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International Searching Authority |
MOIP
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| Applicant's Legal Status |
Legal Entity
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| * | |
| * | |
| * | |
| * | |
| Entry into National Phase under |
Chapter I
* |
| Translation |
|
Recalculate
* The data is based on automatic recognition. Please verify and amend if necessary.
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Quotation for National Phase entry
| Country | Stages | Total | |
|---|---|---|---|
| China | Filing | 1555 | |
| EPO | Filing, Examination | 9310 | |
| Japan | Filing | 592 | |
| South Korea | Filing | 575 | |
| USA | Filing, Examination | 5235 |
Total: 17267 USD
The term for entry into the National Phase has expired. This quotation is for informational purposes only
Abstract[English]
The present disclosure provides a method for aligning fibrils (e.g., protein fibrils, such as, for example, collagen fibrils) in a three-dimensional matrix. The alignment may be described via coherence index (CI). CI is a range of 0 to 1, where 0 corresponds to randomly oriented fibrils, and 1 corresponds to perfect alignment. The fibrils aligned via a method of the present disclosure may have a CI greater than or equal to 0.1, but less than 1. The resulting matrix may have a variety of uses, including, but not limited to, cell culture, tissue mimetics, cell differentiation, or as a drug screening substrate.[French]
La présente invention concerne un procédé d'alignement de fibrilles (par exemple, de fibrilles de protéines, telles que, par exemple, des fibrilles de collagène) dans une matrice tridimensionnelle. L'alignement peut être décrit par l'intermédiaire d'un indice de cohérence (CI). CI est une plage de 0 à 1, où 0 correspond à des fibrilles orientées de manière aléatoire, et 1 correspond à un alignement parfait. Les fibrilles alignées par l'intermédiaire d'un procédé de la présente invention peuvent avoir un CI supérieur ou égal à 0,1, mais inférieur à 1. La matrice résultante peut avoir une variété d'utilisations, comprenant, mais sans y être limitées, une culture cellulaire, des mimétiques de tissu, une différenciation cellulaire, ou une utilisation en tant que substrat de criblage de médicaments.