WO2024157222 - METHOD FOR IDENTIFYING GENETIC VARIANT IN AN EMBRYO
National phase entry is expected:
Publication Number
WO/2024/157222
Publication Date
02.08.2024
International Application No.
PCT/IB2024/050754
International Filing Date
26.01.2024
Title **
[English]
METHOD FOR IDENTIFYING GENETIC VARIANT IN AN EMBRYO
[French]
PROCÉDÉ D'IDENTIFICATION D'UN VARIANT GÉNÉTIQUE DANS UN EMBRYON
Applicants **
EMBRYOME INC.
258 Major St.
Toronto, Ontario M5S 2L6, CA
Inventors
VENNER, Eric
258 Major St.
Toronto, Ontario M5S 2L6, CA
BAINBRIDGE, Matthew
258 Major St.
Toronto, Ontario M5S 2L6, CA
GRUSCHOW, Jeremy
258 Major St.
Toronto, Ontario M5S 2L6, CA
Priority Data
63/441,291
26.01.2023
US
Application details
| Total Number of Claims/PCT | * |
| Number of Independent Claims | * |
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| Number of Multi-Dependent Claims | * |
| Number of Drawings | * |
| Pages for Publication | * |
| Number of Pages with Drawings | * |
| Pages of Specification | * |
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International Searching Authority |
CIPO
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| Applicant's Legal Status |
Legal Entity
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| * | |
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| * | |
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| Entry into National Phase under |
Chapter I
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| Translation |
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Recalculate
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Quotation for National Phase entry
| Country | Stages | Total | |
|---|---|---|---|
| China | Filing | 2280 | |
| EPO | Filing, Examination | 17694 | |
| Japan | Filing | 587 | |
| South Korea | Filing | 574 | |
| USA | Filing, Examination | 8310 |
Total: 29445 USD
The term for entry into the National Phase has expired. This quotation is for informational purposes only
Abstract[English]
The present disclosure provides, in part, a method of identifying a genetic variant in an embryo. The method comprising: (a) obtaining two or more sources of analytes from the embryo; (b) analyzing the two or more sources of analytes to obtain genetic information of each source; (c) comparing the genetic information of each source against one or more reference genome using at least one variant caller, wherein the variant caller identifies variant(s) between each source and the reference genome; and (d) combining the variant(s) to identify a difference that is present only from the sources, wherein the difference is a genetic variant in the embryo.[French]
La présente divulgation propose, en partie, un procédé d'identification d'un variant génétique dans un embryon. Le procédé comprend : (a) l'obtention d'au moins deux sources d'analytes à partir de l'embryon; (b) l'analyse de ces sources d'analytes pour obtenir des informations génétiques de chaque source; (c) la comparaison des informations génétiques de chaque source par rapport à un ou plusieurs génomes de référence à l'aide d'au moins un appelant de variant, l'appelant de variant identifiant un ou plusieurs variants entre chaque source et le génome de référence; et (d) la combinaison du ou des variants pour identifier une différence qui est présente uniquement à partir des sources, la différence étant un variant génétique dans l'embryon..